ID   PESC_NEMVE              Reviewed;         515 AA.
AC   A7SWH1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   ORFNames=v1g194255;
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6;
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC       the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; DS469859; EDO31954.1; -; Genomic_DNA.
DR   RefSeq; XP_001624054.1; XM_001624004.1.
DR   AlphaFoldDB; A7SWH1; -.
DR   SMR; A7SWH1; -.
DR   STRING; 45351.EDO31954; -.
DR   EnsemblMetazoa; EDO31954; EDO31954; NEMVEDRAFT_v1g194255.
DR   GeneID; 5502932; -.
DR   KEGG; nve:5502932; -.
DR   eggNOG; KOG2481; Eukaryota.
DR   HOGENOM; CLU_019619_0_0_1; -.
DR   InParanoid; A7SWH1; -.
DR   OMA; TWIVPHY; -.
DR   OrthoDB; 777920at2759; -.
DR   PhylomeDB; A7SWH1; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0070545; C:PeBoW complex; IBA:GO_Central.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW   rRNA processing.
FT   CHAIN           1..515
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370469"
FT   DOMAIN          318..411
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          477..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          270..327
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   COMPBIAS        480..496
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        497..515
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   515 AA;  60126 MW;  BF8918565D9F3BCB CRC64;
     MGKLKKKGER GAATNYVSRN QALKKLQLSL PDFRRLCILK GIYPVEPKNK KKVNKGSTAN
     KTYYYVKDIQ WLAHEPVLNK FREFKVFLRK LKKAIAKEQP GTADRLEDNK PVYTLDHIVK
     ERYPTFIDAL RDLDDALSML FLFSIMPQTD KIQAAVVQDC RRLSVEFQHY IISSRSLRKV
     FFSIKGIYFQ AEIQGQTITW ITPYQFCQDP PTDVDFRVML TFVDFYKTMM GFINFKLYNN
     LNMHYPPVLA DKTDKKLDTN YCKDTEVEDE VLAALNHTLK IIQTQEEDLE VDEFPIDPNS
     EDAEAIQAQK EEETKLERLK NLFSECKVFL SREVPRETLV FMIRSFGGQV SWDVSTAIGA
     TFAETDESIT HQIVDRPSQG HQFLSRYYIQ PQWVADSINQ GKLLPVEEYF PGEELPPHLS
     PFVKEEEGDY VPPERKAIMD QEMDTNQNEV TEEEEVPDMT REEKELAVAA MPRKDRRLYE
     KIMHSKKKKR SEVRKLESKR KVHDEEKAKK KLKSS