PESC_NEOFI
ID PESC_NEOFI Reviewed; 675 AA.
AC A1CXF4;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN Name=nop7; ORFNames=NFIA_107990;
OS Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=331117;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC / WB 181;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1, nop7 and
CC ytm1. The complex is held together by erb1, which interacts with nop7
CC via its N-terminal domain and with ytm1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; DS027685; EAW25306.1; -; Genomic_DNA.
DR RefSeq; XP_001267203.1; XM_001267202.1.
DR AlphaFoldDB; A1CXF4; -.
DR SMR; A1CXF4; -.
DR STRING; 36630.CADNFIAP00009875; -.
DR EnsemblFungi; EAW25306; EAW25306; NFIA_107990.
DR GeneID; 4593513; -.
DR KEGG; nfi:NFIA_107990; -.
DR VEuPathDB; FungiDB:NFIA_107990; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_1_1_1; -.
DR OMA; TWIVPHY; -.
DR OrthoDB; 777920at2759; -.
DR Proteomes; UP000006702; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..675
FT /note="Pescadillo homolog"
FT /id="PRO_0000370497"
FT DOMAIN 351..470
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 308..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 567..675
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 500..515
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..577
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 75502 MW; 24A44F5CDA27E5DE CRC64;
MGKIKKKGTS GQAKNYITRT QAVRKLQISL PDFRRLCIFK GIYPREPRNK KKASKTSTPN
TTFYYTKDIQ YLLHEPLLRK FREQKAVAKK IARSLGRGEV GDAARLEKNH APKLTLDHVI
KERYPTFIDA LRDLDDALSL LFLFANLPST AHVPPKTIAL CQRLCHEFQH YLITTNSLRK
SFLSIKGIYY QATIQGQDIM WLVPYRFVQR VNGDVDYRIM ATFVDFYTTL LGFVNFRLYS
SIGLRYPPKF DTRSDENGAE LAAFTLEGRG VGDAPKAIEA GNTQATTSTN KEVSKEIQAK
VDDVIKSAGL DEAKEEPAAE TTEESSETID KFEPAAPEAD TLPQPDLSGS EAGSLFAPFT
FYISREAPRA PLEFILRAFG CKRIGWDAVL GDGAFTHDET DTRITHQIVD RPQLPESSLP
AIPAASKDGS DAVQKVKPGT RIPGRTYVQP QWVWDCINEG KLVRPDLYAP GATLPPHLSP
WVKPSRGGYD PKASLAEQEE EGEAELDEDS DEEMEEAAND KKAEAKADVG SESEDEDESV
DGGMDVAGTD DDESESEEEE EDFGGFEEEE AASESEDEEE AARTQHQKEL EAEAAGLPFS
SNGATSDESK KKASQAKKIA AKKRKEEEEL ERQKMMMSRK KRKLLEKMIY SNKKQSEEAA
KLRSKRRKLE KEATK
