PESC_PICGU
ID PESC_PICGU Reviewed; 585 AA.
AC A5DGY0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN Name=NOP7 {ECO:0000255|HAMAP-Rule:MF_03028}; ORFNames=PGUG_02531;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of ERB1, NOP7 and
CC YTM1. The complex is held together by ERB1, which interacts with NOP7
CC via its N-terminal domain and with YTM1 via a high-affinity interaction
CC between the seven-bladed beta-propeller domains of the 2 proteins. The
CC NOP7 complex associates with the 66S pre-ribosome. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; CH408157; EDK38433.2; -; Genomic_DNA.
DR RefSeq; XP_001484802.1; XM_001484752.1.
DR AlphaFoldDB; A5DGY0; -.
DR SMR; A5DGY0; -.
DR STRING; 4929.XP_001484802.1; -.
DR EnsemblFungi; EDK38433; EDK38433; PGUG_02531.
DR GeneID; 5127085; -.
DR KEGG; pgu:PGUG_02531; -.
DR VEuPathDB; FungiDB:PGUG_02531; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_1_1_1; -.
DR InParanoid; A5DGY0; -.
DR OMA; TWIVPHY; -.
DR OrthoDB; 777920at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..585
FT /note="Pescadillo homolog"
FT /id="PRO_0000370500"
FT DOMAIN 341..440
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 444..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 561..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 460..490
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COILED 557..585
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 465..501
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 585 AA; 67102 MW; E4EA1C043ED39D42 CRC64;
MRIKKKGTSG NAKNFITRTQ AVKKLQVSLA DFRRLCIFKG IYPREPRNKK KANKGSTAPV
TFYYAKDIQY LLHEPVLQKF REHKTFAKKL QRALGRGEVS DAARLESNRP KYSLDHVIKE
RYPTFLDALR DLDDPLNMLF LFANMPATDK VSHRITKDAE KLCNQWLAYV AKERLIKKVF
VSIKGVYYQA NVMGQEVRWL VPYKFPTNIP SDVDFRIMMT FLEFYSTLLH FVLYKLYNNA
NLIYPPTIDI EKLKGIGGLS AYILQTKDSV NPLIPKTKAA QTDAAGTKLD DKEISKAIEA
DQKDDDEDVE PGVDEVELDE FSATNKTTGD LLSQPSQYAS PTSTLFSKFV FYVGREVPLD
ILEFCILSCG GSLVSEIAMD DLKINHPEAY KNLDLSTITH QIVDRPKVAS KVAGRTYIQP
QWIFDSLNQG SLLPVNSYAP GETLPPHLSP WGDAAGYDPE SKKTEEGEQE DEEEEEEEVE
VEEEDENQEE PEEEDEDVKE QRELEMEASG VKFSDTVEDK KKKPSKKRSA EEEEKDLKKI
MMTNKQRKLY NKMQYGINKK ETRQDELAKK RRKIDKKKAE LQKLN
