PESC_SCHPO
ID PESC_SCHPO Reviewed; 607 AA.
AC O60164; Q9US84;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
DE AltName: Full=Nucleolar protein 7 homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN Name=ppp1; Synonyms=nop7; ORFNames=SPBC19F5.05c, SPBC25D12.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 65-116, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
CC -!- FUNCTION: Component of the NOP7 complex, which is required for
CC maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S
CC ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBUNIT: Component of the NOP7 complex, composed of erb1/SPBC4F6.13c,
CC ppp1/SPBC19F5.05c and ytm1/SPAC890.04c. Within the NOP7 complex
CC erb1/SPBC4F6.13c appears to interact directly with ppp1/SPBC19F5.05c
CC and ytm1/SPAC890.04c. The NOP7 complex also associates with the 66S
CC pre-ribosome. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03028,
CC ECO:0000269|PubMed:10759889}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; CU329671; CAA18653.1; -; Genomic_DNA.
DR EMBL; AB027979; BAA87283.1; -; Genomic_DNA.
DR PIR; T39823; T39823.
DR RefSeq; NP_596543.1; NM_001022464.2.
DR AlphaFoldDB; O60164; -.
DR SMR; O60164; -.
DR BioGRID; 277184; 9.
DR STRING; 4896.SPBC19F5.05c.1; -.
DR iPTMnet; O60164; -.
DR SwissPalm; O60164; -.
DR MaxQB; O60164; -.
DR PaxDb; O60164; -.
DR PRIDE; O60164; -.
DR EnsemblFungi; SPBC19F5.05c.1; SPBC19F5.05c.1:pep; SPBC19F5.05c.
DR GeneID; 2540659; -.
DR KEGG; spo:SPBC19F5.05c; -.
DR PomBase; SPBC19F5.05c; ppp1.
DR VEuPathDB; FungiDB:SPBC19F5.05c; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_0_0_1; -.
DR InParanoid; O60164; -.
DR OMA; TWIVPHY; -.
DR PhylomeDB; O60164; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:O60164; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005730; C:nucleolus; IDA:PomBase.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0070545; C:PeBoW complex; ISO:PomBase.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR Gene3D; 3.40.50.10190; -; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PTHR12221; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; SSF52113; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Reference proteome; Ribosome biogenesis;
KW rRNA processing.
FT CHAIN 1..607
FT /note="Pescadillo homolog"
FT /id="PRO_0000186191"
FT DOMAIN 348..441
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 301..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 497..604
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 310..324
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..565
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 588..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 607 AA; 69189 MW; 3222C4E7903A7351 CRC64;
MARVKQKGKA GAARIYITRN QALKKLQLTL ADFRRICILK GVYPREPKNK KKANKGSTAP
VTFYYTKDIQ YLLHEPIVQK FREYKVFARK LSKALGKGEL ETAKRLEARK PTYSLDHIIK
ERYPTFHDAL KDIDDALSML FLFSTMPVTD KIGAATVANC ERLCAEFQHY VIRSNSLRKA
FLSIKGIYYQ AEIFGEQITW IVPYKFAQSV PTDVDFRIMH TFLEFYQALM GFVNFKLYNT
LGLRYPPKID VAKSESAAGL AAYELEESSS LPAIVHGNNK NARKNIATLK SKIRDIVNSD
ANVVEQSEKT TEDADEEPET EENLDEFKPA DGADNEDSKS LVSHISSSNT SLFSNFTFFL
SREVPRFSLE FVIRAFGGKV GWDPILGSGS PFSESDPVIT HHICDRPHIS QKYEGRIYIQ
PQWVYDSINK GILERTDLYA CGATLPPHLS PFVKVGENDY DPEAELSAEE NDDVSEALDD
NISGEAVPIS KKNDEPENVE QIDDAEEEDL EHQRELEAEA GGVAYSEYVK QNSKSAKKTK
KRQRDTLTAE EKEEKEAKEL SKMMMSNKQR KLYSKLKNEN SKNENYNNAL RNRKRDIEKR
KKLKVEN
