ID   PESC_XENLA              Reviewed;         574 AA.
AC   Q7ZY69;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN   Name=pes1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=17727835; DOI=10.1016/j.ydbio.2007.07.037;
RA   Gessert S., Maurus D., Roessner A., Kuehl M.;
RT   "Pescadillo is required for Xenopus laevis eye development and neural crest
RT   migration.";
RL   Dev. Biol. 310:99-112(2007).
CC   -!- FUNCTION: Component of the PeBoW complex, which is required for
CC       maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S
CC       ribosome (By similarity). Required for neural crest migration and eye
CC       development. {ECO:0000255|HAMAP-Rule:MF_03028,
CC       ECO:0000269|PubMed:17727835}.
CC   -!- SUBUNIT: Component of the PeBoW complex, composed of bop1, pes1 and
CC       wdr12. The complex is held together by bop1, which interacts with pes1
CC       via its N-terminal domain and with wdr12 via a high-affinity
CC       interaction between the seven-bladed beta-propeller domains of the 2
CC       proteins. The PeBoW complex associates with the 66S pre-ribosome.
CC       {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC       Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC   -!- DEVELOPMENTAL STAGE: Maternally expressed. Strongly expressed in the
CC       anterior neural plate at stage 18. Expressed in the migrating cranial
CC       neural crest and the developing eye at stage 23. Also expressed in the
CC       midbrain-hindbrain boundary, migrating neural crest cells and the
CC       periocular mesenchyme at stages 26-31. Expression appears to require
CC       Wnt-4 activity. {ECO:0000269|PubMed:17727835}.
CC   -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC       Rule:MF_03028}.
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DR   EMBL; BC043950; AAH43950.1; -; mRNA.
DR   RefSeq; NP_001080557.1; NM_001087088.1.
DR   AlphaFoldDB; Q7ZY69; -.
DR   SMR; Q7ZY69; -.
DR   PRIDE; Q7ZY69; -.
DR   DNASU; 380249; -.
DR   GeneID; 380249; -.
DR   KEGG; xla:380249; -.
DR   CTD; 380249; -.
DR   Xenbase; XB-GENE-480674; pes1.S.
DR   OrthoDB; 777920at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 380249; Expressed in pancreas and 19 other tissues.
DR   GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR   GO; GO:0070545; C:PeBoW complex; ISS:UniProtKB.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; ISS:UniProtKB.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10190; -; 1.
DR   HAMAP; MF_03028; Pescadillo; 1.
DR   InterPro; IPR001357; BRCT_dom.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR010613; PES.
DR   PANTHER; PTHR12221; PTHR12221; 1.
DR   Pfam; PF16589; BRCT_2; 1.
DR   Pfam; PF06732; Pescadillo_N; 1.
DR   SMART; SM00292; BRCT; 1.
DR   SUPFAM; SSF52113; SSF52113; 1.
DR   PROSITE; PS50172; BRCT; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..574
FT                   /note="Pescadillo homolog"
FT                   /id="PRO_0000370447"
FT   DOMAIN          323..416
FT                   /note="BRCT"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT   REGION          289..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          452..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..478
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   574 AA;  67117 MW;  3886A2DA331619BF CRC64;
     MGGLEKKKYE RGSATNYITR NKARKKLQLS LPDFRRLCIL KGIYPHEPKH KKKVNKGSTA
     PRTFYLLKDI KFLLHEPIVG KFREYKVFVR RLRKAYGKRE WDSVDRIRDN KPSYKLDHII
     KERYPTFIDA VRDLDDALSM CFLFSTFPRT GKCHVQTIQL CRRLSVEFLN YVIDSRSLRK
     VFLSIKGIYY QADILGQTLT WITPYAFSHD HPTDVDYRVM ATFTEFYTTL LGFVNFHLYQ
     TLNLQYPPKL DSFSEVDLKS DGEDKYALET EVYMEKLAAL SASLSRVIPS EPNDDTEVDE
     FPADPENAGL EEEQKRQLQE EEKHKSLFVG LKFFLNREVP RDALAFIIRS FGGEVSWDAS
     VCIGATYNST DPSITHHIVD RPSIQTQIIN RYYLQPQWVF DCVNARLLLP VEDYFPGVLL
     PPHLSPFVHE KEGDYIPPEK LRLMAMQKGE NLGLDEEDDD DDDDDEEEDD DDDEEEEDKK
     LRQLENKKVG QKNLNVKVTA GKVKVEDRTQ VAEQEKNEEK RLAIMMMKKK EKYLYNKIMF
     GKKRKVREAN KLALKRKAHD EAVKVERKKK AKKH