PESTE_DROME
ID PESTE_DROME Reviewed; 555 AA.
AC B7Z031; Q8SXU4; Q9VLU8;
DT 30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Protein peste {ECO:0000303|PubMed:16020694};
GN Name=pes {ECO:0000312|FlyBase:FBgn0031969};
GN ORFNames=CG7228 {ECO:0000312|FlyBase:FBgn0031969};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|Proteomes:UP000000803};
RN [1] {ECO:0000312|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000312|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL89869.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL89869.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:AAL89869.1};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP FUNCTION (MICROBIAL INFECTION), AND DISRUPTION PHENOTYPE (MICROBIAL
RP INFECTION).
RX PubMed=16020694; DOI=10.1126/science.1116006;
RA Philips J.A., Rubin E.J., Perrimon N.;
RT "Drosophila RNAi screen reveals CD36 family member required for
RT mycobacterial infection.";
RL Science 309:1251-1253(2005).
RN [5] {ECO:0000305}
RP DEVELOPMENTAL STAGE.
RX PubMed=21948708; DOI=10.1387/ijdb.103254lh;
RA Herboso L., Talamillo A., Perez C., Barrio R.;
RT "Expression of the Scavenger Receptor Class B type I (SR-BI) family in
RT Drosophila melanogaster.";
RL Int. J. Dev. Biol. 55:603-611(2011).
CC -!- FUNCTION: (Microbial infection) Plays a role in mycobacterial
CC infection. Mediates infection by M.fortuitum and uptake of M.smegmatis.
CC {ECO:0000269|PubMed:16020694}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: Detected in all examined tissues of L3 instar
CC larvae. Expression in the ring gland and anterior spiracles increases
CC during development. In the ovaries it is predominantly expressed in one
CC pole, and in the anterior spiracles it is mostly expressed in the
CC spiracular gland. Ubiquitously expressed throughout the testis and
CC alimentary tract. {ECO:0000269|PubMed:21948708}.
CC -!- DISRUPTION PHENOTYPE: (Microbial infection) RNAi-mediated knockdown
CC blocks infection by M.fortuitum and uptake of M.smegmatis.
CC {ECO:0000269|PubMed:16020694}.
CC -!- MISCELLANEOUS: The name 'peste' means plague in Latin and derives from
CC its role in bacterial infection. {ECO:0000305|PubMed:16020694}.
CC -!- SIMILARITY: Belongs to the CD36 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL89869.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF52584.3; -; Genomic_DNA.
DR EMBL; AE014134; AAN10649.2; -; Genomic_DNA.
DR EMBL; AE014134; ACL83014.1; -; Genomic_DNA.
DR EMBL; AE014134; AHN54245.1; -; Genomic_DNA.
DR EMBL; AE014134; AHN54246.1; -; Genomic_DNA.
DR EMBL; AY084131; AAL89869.1; ALT_INIT; mRNA.
DR RefSeq; NP_001137808.1; NM_001144336.3.
DR RefSeq; NP_001285731.1; NM_001298802.1.
DR RefSeq; NP_001285732.1; NM_001298803.1.
DR RefSeq; NP_609168.2; NM_135324.3.
DR RefSeq; NP_723328.2; NM_164777.3.
DR AlphaFoldDB; B7Z031; -.
DR SMR; B7Z031; -.
DR IntAct; B7Z031; 2.
DR STRING; 7227.FBpp0289420; -.
DR GlyGen; B7Z031; 7 sites.
DR PaxDb; B7Z031; -.
DR PRIDE; B7Z031; -.
DR DNASU; 34087; -.
DR EnsemblMetazoa; FBtr0114550; FBpp0113042; FBgn0031969.
DR EnsemblMetazoa; FBtr0300183; FBpp0289420; FBgn0031969.
DR EnsemblMetazoa; FBtr0331674; FBpp0304064; FBgn0031969.
DR EnsemblMetazoa; FBtr0344860; FBpp0311175; FBgn0031969.
DR EnsemblMetazoa; FBtr0344861; FBpp0311176; FBgn0031969.
DR GeneID; 34087; -.
DR KEGG; dme:Dmel_CG7228; -.
DR CTD; 30228; -.
DR FlyBase; FBgn0031969; pes.
DR VEuPathDB; VectorBase:FBgn0031969; -.
DR eggNOG; KOG3776; Eukaryota.
DR GeneTree; ENSGT00940000153372; -.
DR HOGENOM; CLU_019853_5_2_1; -.
DR InParanoid; B7Z031; -.
DR OMA; GTCGQVH; -.
DR OrthoDB; 1106566at2759; -.
DR PhylomeDB; B7Z031; -.
DR BioGRID-ORCS; 34087; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 34087; -.
DR PRO; PR:B7Z031; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0031969; Expressed in cleaving embryo and 39 other tissues.
DR ExpressionAtlas; B7Z031; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005044; F:scavenger receptor activity; IBA:GO_Central.
DR InterPro; IPR002159; CD36_fam.
DR PANTHER; PTHR11923; PTHR11923; 1.
DR Pfam; PF01130; CD36; 1.
DR PRINTS; PR01609; CD36FAMILY.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..555
FT /note="Protein peste"
FT /id="PRO_0000438383"
FT TOPO_DOM 1..7
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..434
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 456..555
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 129
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 342
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 555 AA; 62252 MW; 43B059C07B4D7CE1 CRC64;
MTSRTRHCAR LGIVLLGICC IASGIYLFRN WIDMFTRMRG QEMALSPNSR SFEGWKVSPL
PLDFDIYLFN WTNPDDFYVG SNKKPHFEQL GPYRFREKPD KVDIEWHNHN ASVSFHKKSW
FYFDAAGSNG SLWDKVTTVN SVAHSAARRA AVDWFARTGV NIANKLYRQG VTITKTVDEM
LFKGYEHPFI SVGKLLRPQD VPYKRIGYHY PRNGSSEFDG DINMFTGADD IAKMGQIHTW
NNLTHTGAFE GTCGQVHGSM GEFFPPNLGT KDTVYMYMPK MCRAIPLDYV ETVTVHGVTA
YKFSGTRHAV DNGTLYPDTR CYCVGGKCMP SGVINIGPCS FNASVYMSFP HFYMADPSYL
EAIEGLRPER EKHEFFMALE PNAGVPMDVG GGFQANYYME PIPGITLYEN VPTVMIPMMW
CEERVRVSEE IAADIALVPL IVLLGQIVTG ILLAGGLICT CWYPTRQVTH FCHSDPKAKA
SVLRPLNAFG VNSSAATAPV AQLFRNNISS SGNERVGVRL LDYNRDSGIR LESGTMESSH
RERLISEDSP DVVVR
