PEVD1_VERDV
ID PEVD1_VERDV Reviewed; 155 AA.
AC G2WWV6;
DT 07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT 16-NOV-2011, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Effector protein PevD1 {ECO:0000305};
DE AltName: Full=Hypersensitive response-inducing protein PevD1 {ECO:0000303|PubMed:21691787};
DE Flags: Precursor;
GN Name=PevD1 {ECO:0000303|PubMed:21691787};
GN ORFNames=VDAG_02735 {ECO:0000312|EMBL:EGY21211.1};
OS Verticillium dahliae (strain VdLs.17 / ATCC MYA-4575 / FGSC 10137)
OS (Verticillium wilt).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=498257;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VdLs.17 / ATCC MYA-4575 / FGSC 10137;
RX PubMed=21829347; DOI=10.1371/journal.ppat.1002137;
RA Klosterman S.J., Subbarao K.V., Kang S., Veronese P., Gold S.E.,
RA Thomma B.P.H.J., Chen Z., Henrissat B., Lee Y.-H., Park J.,
RA Garcia-Pedrajas M.D., Barbara D.J., Anchieta A., de Jonge R., Santhanam P.,
RA Maruthachalam K., Atallah Z., Amyotte S.G., Paz Z., Inderbitzin P.,
RA Hayes R.J., Heiman D.I., Young S., Zeng Q., Engels R., Galagan J.,
RA Cuomo C.A., Dobinson K.F., Ma L.-J.;
RT "Comparative genomics yields insights into niche adaptation of plant
RT vascular wilt pathogens.";
RL PLoS Pathog. 7:E1002137-E1002137(2011).
RN [2]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21691787; DOI=10.1007/s00253-011-3405-1;
RA Wang B., Yang X., Zeng H., Liu H., Zhou T., Tan B., Yuan J., Guo L.,
RA Qiu D.;
RT "The purification and characterization of a novel hypersensitive-like
RT response-inducing elicitor from Verticillium dahliae that induces
RT resistance responses in tobacco.";
RL Appl. Microbiol. Biotechnol. 93:191-201(2012).
RN [3]
RP FUNCTION, AND DOMAIN.
RX PubMed=24080193; DOI=10.1016/j.micres.2013.08.001;
RA Liu W., Zeng H., Liu Z., Yang X., Guo L., Qiu D.;
RT "Mutational analysis of the Verticillium dahliae protein elicitor PevD1
RT identifies distinctive regions responsible for hypersensitive response and
RT systemic acquired resistance in tobacco.";
RL Microbiol. Res. 169:476-482(2014).
RN [4]
RP FUNCTION.
RX PubMed=24337817; DOI=10.1007/s00299-013-1546-7;
RA Bu B., Qiu D., Zeng H., Guo L., Yuan J., Yang X.;
RT "A fungal protein elicitor PevD1 induces Verticillium wilt resistance in
RT cotton.";
RL Plant Cell Rep. 33:461-470(2014).
RN [5]
RP SUBUNIT.
RX PubMed=22750869; DOI=10.1107/s1744309112020556;
RA Han L., Liu Z., Liu X., Qiu D.;
RT "Purification, crystallization and preliminary X-ray diffraction analysis
RT of the effector protein PevD1 from Verticillium dahliae.";
RL Acta Crystallogr. F 68:802-805(2012).
RN [6]
RP DISULFIDE BONDS.
RX PubMed=28633330; DOI=10.1093/jxb/erx192;
RA Zhou R., Zhu T., Han L., Liu M., Xu M., Liu Y., Han D., Qiu D., Gong Q.,
RA Liu X.;
RT "The asparagine-rich protein NRP interacts with the Verticillium effector
RT PevD1 and regulates the subcellular localization of cryptochrome 2.";
RL J. Exp. Bot. 68:3427-3440(2017).
CC -!- FUNCTION: Effector protein (PubMed:21691787, PubMed:24080193,
CC PubMed:24337817). Elicits a hypersensitive response (HR) in tobacco
CC plants (N.tabacum) and cotton (G.hirsutum) (PubMed:21691787,
CC PubMed:24080193, PubMed:24337817). Boosts systemic acquired resistance
CC (SAR) to tobacco mosaic virus (TMV) infection in N.tabacum and to
CC V.dhaliae infection in primed cotton seedlings (PubMed:21691787,
CC PubMed:24080193, PubMed:24337817). {ECO:0000269|PubMed:21691787,
CC ECO:0000269|PubMed:24080193, ECO:0000269|PubMed:24337817}.
CC -!- SUBUNIT: Monomer (PubMed:22750869). Interacts with Arabidopsis thaliana
CC NRP (PubMed:28633330). {ECO:0000269|PubMed:22750869,
CC ECO:0000269|PubMed:28633330}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21691787}.
CC -!- DOMAIN: The N-terminal region (1-98) is sufficient for induction of SAR
CC of N.tabacum to TMV infection. The C-terminal region (99-155) is
CC sufficient for eliciting HR in N.tabacum.
CC {ECO:0000269|PubMed:24080193}.
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DR EMBL; DS572698; EGY21211.1; -; Genomic_DNA.
DR RefSeq; XP_009651683.1; XM_009653388.1.
DR AlphaFoldDB; G2WWV6; -.
DR SMR; G2WWV6; -.
DR EnsemblFungi; EGY21211; EGY21211; VDAG_02735.
DR GeneID; 20704198; -.
DR KEGG; vda:VDAG_02735; -.
DR eggNOG; ENOG502SP40; Eukaryota.
DR HOGENOM; CLU_144932_1_0_1; -.
DR InParanoid; G2WWV6; -.
DR OMA; GPADEIC; -.
DR PHI-base; PHI:8520; -.
DR Proteomes; UP000001611; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR032382; AltA1.
DR Pfam; PF16541; AltA1; 1.
DR PROSITE; PS51895; AA1; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..155
FT /note="Effector protein PevD1"
FT /id="PRO_0000451206"
FT DOMAIN 33..148
FT /note="AA1-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01243"
FT DISULFID 70..84
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01243,
FT ECO:0000269|PubMed:28633330"
FT DISULFID 125..135
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01243,
FT ECO:0000269|PubMed:28633330"
SQ SEQUENCE 155 AA; 16230 MW; 230EA4200C0296BF CRC64;
MQFTLAAAAA LFGASALAAP ASPGSTGAPP DPNMYENIDI ADFNVRKGED GTIKYVNFKL
SGDDADGLLC EAQNPGLPSN VITCGESKYR FALSSGKQYE FALSLYHELG LAVGFYGTGE
IFTHCRAGGL GDFICQQQNP TTIVIDSLPD APAEA
