ID   PEX10_CAEEL             Reviewed;         314 AA.
AC   C0HKD7; P46579; Q5TYM1; Q7Z259;
DT   25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2017, sequence version 1.
DT   03-AUG-2022, entry version 25.
DE   RecName: Full=Putative peroxisomal biogenesis factor 10 {ECO:0000305};
DE   AltName: Full=Peroxin-10 {ECO:0000305};
GN   Name=prx-10 {ECO:0000312|WormBase:C34E10.4a};
GN   ORFNames=C34E10.4 {ECO:0000312|WormBase:C34E10.4a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION.
RX   PubMed=20176933; DOI=10.1073/pnas.0912308107;
RA   Zhang S.O., Box A.C., Xu N., Le Men J., Yu J., Guo F., Trimble R.,
RA   Mak H.Y.;
RT   "Genetic and dietary regulation of lipid droplet expansion in
RT   Caenorhabditis elegans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:4640-4645(2010).
CC   -!- FUNCTION: May be involved in the import of proteins into the
CC       peroxisome. Plays a role in lipid storage, most likely through its role
CC       in peroxisome function. {ECO:0000305|PubMed:20176933}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:O60683}; Single-pass membrane protein
CC       {ECO:0000305}.
CC   -!- MISCELLANEOUS: Complex locus in which transcription results in the
CC       production of one large primary transcript that gives rise to two
CC       functionally distinct proteins, wars-2 and prx-10.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; BX284603; CCD66656.1; -; Genomic_DNA.
DR   RefSeq; NP_001021200.2; NM_001026029.3.
DR   AlphaFoldDB; C0HKD7; -.
DR   EnsemblMetazoa; C34E10.4a.1; C34E10.4a.1; WBGene00006946.
DR   EnsemblMetazoa; C34E10.4a.2; C34E10.4a.2; WBGene00006946.
DR   GeneID; 175719; -.
DR   KEGG; cel:CELE_C34E10.4; -.
DR   CTD; 175719; -.
DR   WormBase; C34E10.4a; CE44834; WBGene00006946; prx-10.
DR   GeneTree; ENSGT00940000153724; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006946; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; C0HKD7; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004830; F:tryptophan-tRNA ligase activity; IBA:GO_Central.
DR   GO; GO:0070183; P:mitochondrial tryptophanyl-tRNA aminoacylation; IBA:GO_Central.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0006436; P:tryptophanyl-tRNA aminoacylation; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR027370; Znf-RING_LisH.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   Pfam; PF13445; zf-RING_UBOX; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Zinc; Zinc-finger.
FT   CHAIN           1..314
FT                   /note="Putative peroxisomal biogenesis factor 10"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000441752"
FT   TRANSMEM        198..218
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         255..300
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ   SEQUENCE   314 AA;  36002 MW;  2C8D62CA3591EA85 CRC64;
     MNTYVAEIGE IVRSQRRDEE YIEDITERLS RVSKELLGQR TWIRWFPYLK SIASTLYYTS
     TVVLGNQTLG EEYVHLFESN GLERTVPSIP SRISFVLLHS AFPLISNYLI QKAESTLTHP
     STESFLGIPI RKNQKARQSF LDVFFWLRTK LFPQLQRAHI ALFYITGAYY SIARRFTGIR
     FLSASAHSDI PALKVYRFLG YITLIQLAVS IGISLYSFLE QEKFNNKLKK EKKENNGGSD
     RNLDENSLFH PTFQCSICLE NKNPSALFCG HLFCWTCIQE HAVAATSSAS TSSARCPQCR
     LEFQPRDVTP LLNL