ID   PEX10_DICDI             Reviewed;         374 AA.
AC   Q54S31;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Peroxisome biogenesis factor 10;
DE   AltName: Full=Peroxin-10;
DE   AltName: Full=Peroxisomal biogenesis factor 10;
DE   AltName: Full=Peroxisome assembly protein 10;
GN   Name=pex10; ORFNames=DDB_G0282693;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in the biogenesis of peroxisomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66206.2; -; Genomic_DNA.
DR   RefSeq; XP_640208.2; XM_635116.2.
DR   AlphaFoldDB; Q54S31; -.
DR   STRING; 44689.DDB0238052; -.
DR   PaxDb; Q54S31; -.
DR   EnsemblProtists; EAL66206; EAL66206; DDB_G0282693.
DR   GeneID; 8623748; -.
DR   KEGG; ddi:DDB_G0282693; -.
DR   dictyBase; DDB_G0282693; pex10.
DR   eggNOG; KOG0317; Eukaryota.
DR   HOGENOM; CLU_041707_2_0_1; -.
DR   InParanoid; Q54S31; -.
DR   OMA; RNWIKYN; -.
DR   PhylomeDB; Q54S31; -.
DR   Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-DDI-9033241; Peroxisomal protein import.
DR   PRO; PR:Q54S31; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; ISS:dictyBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; ISS:dictyBase.
DR   GO; GO:0007031; P:peroxisome organization; ISS:dictyBase.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW   Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..374
FT                   /note="Peroxisome biogenesis factor 10"
FT                   /id="PRO_0000346863"
FT   TRANSMEM        246..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         322..360
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   374 AA;  44081 MW;  11068D99155E5DCC CRC64;
     MSNVQSQSNS HHPVHNIVNR SPTSRSEQQI RSIPPTNNNN NNNNNSINNI NNNTQRQPLN
     NNNNNNNNIN RNNSNLYPSY ADQPDILRSS QKDEYYKKLF EDQCFEMLTR ITGPRFIMNR
     QSESKLLANT IYYLLTTMIG SQTLGEEYCN LRKIKDKTFS IPSIPDRIKL YFFHLLAPYL
     IKKSLPKLFQ RHPKLYILKE IFPKFERLHL ALFYFNGSYF EFSKRLSDIR YIFNRKIDQK
     RPKYDILGLL IIIQILLSTF MYLKENSFFL KQQQKDGGCN GDGEEDNQDL NKDIKIEQVD
     SVINNNNQDQ NNNQEEEEEQ KCTLCLEVRT HTTATICGHL FCWHCITEWC NNKEQCPVCR
     CPISIRTCVP LYNY