PEX10_MOUSE
ID PEX10_MOUSE Reviewed; 324 AA.
AC B1AUE5;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Peroxisome biogenesis factor 10;
DE AltName: Full=Peroxin-10;
DE AltName: Full=Peroxisomal biogenesis factor 10;
DE AltName: Full=Peroxisome assembly protein 10;
GN Name=Pex10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Somewhat implicated in the biogenesis of peroxisomes.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PEX19. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Peripheral
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR EMBL; AL670413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466594; EDL14991.1; -; Genomic_DNA.
DR EMBL; BC147304; AAI47305.1; -; mRNA.
DR EMBL; BC147305; AAI47306.1; -; mRNA.
DR CCDS; CCDS19021.1; -.
DR RefSeq; NP_001035866.1; NM_001042407.1.
DR AlphaFoldDB; B1AUE5; -.
DR BioGRID; 579973; 2.
DR STRING; 10090.ENSMUSP00000099469; -.
DR iPTMnet; B1AUE5; -.
DR PhosphoSitePlus; B1AUE5; -.
DR EPD; B1AUE5; -.
DR MaxQB; B1AUE5; -.
DR PaxDb; B1AUE5; -.
DR PeptideAtlas; B1AUE5; -.
DR PRIDE; B1AUE5; -.
DR ProteomicsDB; 301791; -.
DR Antibodypedia; 26727; 174 antibodies from 27 providers.
DR Ensembl; ENSMUST00000103180; ENSMUSP00000099469; ENSMUSG00000029047.
DR GeneID; 668173; -.
DR KEGG; mmu:668173; -.
DR UCSC; uc008wcs.1; mouse.
DR CTD; 5192; -.
DR MGI; MGI:2684988; Pex10.
DR VEuPathDB; HostDB:ENSMUSG00000029047; -.
DR eggNOG; KOG0317; Eukaryota.
DR GeneTree; ENSGT00510000048446; -.
DR HOGENOM; CLU_041707_1_0_1; -.
DR InParanoid; B1AUE5; -.
DR OMA; RNWIKYN; -.
DR OrthoDB; 1593722at2759; -.
DR PhylomeDB; B1AUE5; -.
DR TreeFam; TF326491; -.
DR Reactome; R-MMU-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-MMU-9033241; Peroxisomal protein import.
DR BioGRID-ORCS; 668173; 11 hits in 73 CRISPR screens.
DR PRO; PR:B1AUE5; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; B1AUE5; protein.
DR Bgee; ENSMUSG00000029047; Expressed in yolk sac and 216 other tissues.
DR Genevisible; B1AUE5; MM.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; ISO:MGI.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:MGI.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR GO; GO:0007031; P:peroxisome organization; ISO:MGI.
DR GO; GO:0016558; P:protein import into peroxisome matrix; ISO:MGI.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..324
FT /note="Peroxisome biogenesis factor 10"
FT /id="PRO_0000346862"
FT ZN_FING 271..309
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT REGION 119..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 37157 MW; 421ADFECDB413B35 CRC64;
MARAGAPEVI RAAQKDEYYL GGLRSAAGEA LHSLAGAKKW LEWRKEIELL SDIAYFGLTT
IAGYQTLGEE YVGIIQVDPS QQRVPSRLRR AALVALHAVL PYLLDKALLP LEQELQADGD
APRASQGSLL PGGRSRSGAR RWVRHHAATL TEQQRKALQR AVFILRQGFA CLHRLHVAWF
YIHGTFYHLA KRLAGITYLR TRRLPGEDQK ARTSYGLLGL ISLLHLVLSM GLRLYSFRQK
QRARKEWRLH RNLSHRRSSL EDRAVCRTPL CTLCLEERRH STATPCGHLF CWECITEWCN
TKTECPLCRE KFPPQKLVYL RHYR
