ID   PEX10_PICPA             Reviewed;         419 AA.
AC   Q92265;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Peroxisome biogenesis factor 10;
DE   AltName: Full=Peroxin-10;
DE   AltName: Full=Peroxisomal biogenesis factor 10;
DE   AltName: Full=Peroxisome assembly protein 10;
DE   AltName: Full=Peroxisome assembly protein PAS7;
GN   Name=PEX10; Synonyms=PAS7;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7565793; DOI=10.1128/mcb.15.11.6406;
RA   Kalish J.E., Theda C., Morrell J.C., Berg J.M., Gould S.J.;
RT   "Formation of the peroxisome lumen is abolished by loss of Pichia pastoris
RT   Pas7p, a zinc-binding integral membrane protein of the peroxisome.";
RL   Mol. Cell. Biol. 15:6406-6419(1995).
CC   -!- FUNCTION: Necessary for peroxisome assembly, essential for import of
CC       both PTS1 and PTS2 proteins, and required for the establishment of the
CC       peroxisome lumen.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; U70066; AAB09086.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q92265; -.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..419
FT                   /note="Peroxisome biogenesis factor 10"
FT                   /id="PRO_0000056379"
FT   ZN_FING         298..360
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   MUTAGEN         313
FT                   /note="C->S: Loss of activity."
FT   MUTAGEN         315
FT                   /note="H->W: Loss of activity."
FT   MUTAGEN         316
FT                   /note="C->S: No loss of activity."
FT   MUTAGEN         318
FT                   /note="C->S: Loss of activity."
SQ   SEQUENCE   419 AA;  47948 MW;  8D073E48A956AB85 CRC64;
     MPPSEEIKLR AVSPRPDFKA NYLEFANAPA IVRANQKDSY FETVLRDKLQ NVIQIFKGQR
     FTHTHPEEIG VAAKALYLSL TTLLGTKTLG EEYVDLIYVS RDGKRIPRYL ARAGFIFAYA
     ILPYFLTRLF RRLKSSSTPK DEVTEEKINK ELPISLRIEK YLSNMSYSKV LDTIMNLHIA
     VFYFSGQFYN ISKRFFSMRY AFGHKINKER TPNGNYELLG GLIVLQLVMK SLGGFKGLIG
     SFTGNDEHDE SNLRANNKDI MYGIPSEEEQ EEAKQQLGII DLSDPGQLPY IPESSRQCML
     CLSYMTNPTA ANCGHCFCWS CIIDWCKERQ TVLCVGKKCW NSNCYHCIRL FYIPTLNKIC
     FFFLLSFLSV RAASKEFKST KEEFAELFNE ELADIAGEDP HCPGPFPTGR TLGYFLVVF