PEX10_SCHPO
ID PEX10_SCHPO Reviewed; 306 AA.
AC Q9UUF0; O13628;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Peroxisome biogenesis factor 10;
DE AltName: Full=Peroxin-10;
DE AltName: Full=Peroxisomal biogenesis factor 10;
DE AltName: Full=Peroxisome assembly protein 10;
GN Name=pas4; ORFNames=pi036, SPBC17A3.10;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=10620777;
RX DOI=10.1002/(sici)1097-0061(20000115)16:1<71::aid-yea505>3.0.co;2-5;
RA Machida M., Yamazaki S., Kunihiro S., Tanaka T., Kushida N., Jinno K.,
RA Haikawa Y., Yamazaki J., Yamamoto S., Sekine M., Oguchi A., Nagai Y.,
RA Sakai M., Aoki K., Ogura K., Kudoh Y., Kikuchi H., Zhang M.Q., Yanagida M.;
RT "A 38 kb segment containing the cdc2 gene from the left arm of fission
RT yeast chromosome II: sequence analysis and characterization of the genomic
RT DNA and cDNAs encoded on the segment.";
RL Yeast 16:71-80(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Somewhat implicated in the biogenesis of peroxisomes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Peripheral
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA21416.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB004537; BAA21416.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CU329671; CAB51769.1; -; Genomic_DNA.
DR PIR; T39702; T39702.
DR RefSeq; NP_595592.1; NM_001021488.2.
DR AlphaFoldDB; Q9UUF0; -.
DR BioGRID; 276325; 23.
DR STRING; 4896.SPBC17A3.10.1; -.
DR PaxDb; Q9UUF0; -.
DR PRIDE; Q9UUF0; -.
DR EnsemblFungi; SPBC17A3.10.1; SPBC17A3.10.1:pep; SPBC17A3.10.
DR GeneID; 2539774; -.
DR KEGG; spo:SPBC17A3.10; -.
DR PomBase; SPBC17A3.10; pas4.
DR VEuPathDB; FungiDB:SPBC17A3.10; -.
DR eggNOG; KOG0317; Eukaryota.
DR HOGENOM; CLU_918773_0_0_1; -.
DR InParanoid; Q9UUF0; -.
DR OMA; KCALCME; -.
DR Reactome; R-SPO-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-SPO-9033241; Peroxisomal protein import.
DR PRO; PR:Q9UUF0; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:PomBase.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISM:PomBase.
DR GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR GO; GO:0070647; P:protein modification by small protein conjugation or removal; IC:PomBase.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..306
FT /note="Peroxisome biogenesis factor 10"
FT /id="PRO_0000056380"
FT ZN_FING 256..294
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 306 AA; 34303 MW; 2AE11B6052A006CC CRC64;
MHLSAHIDPL QIILCTEIDE ACIQFIKSQI EGIARACGPR MQANFEGVLI PYVDVLGKFL
YRACCLRYAT MGEEAARIVL AKQDRSKGLV LATTGERMTS LIFSLVIDLV GVHVNKLLKQ
ASYSSSFKLP FGLRNLLPEA VISKEKHLVY ILNSFKPILL KLVSIIRFLC LTMKGHCATV
SQLLLGLKYI SLDEINPEEK KKVLTLLLLL GSRLIASILQ HSNSYFDQHT ISSITDERDL
EDKNKLPFIP EGNRKCSLCM EFIHCPAATE CGHIFCWSCI NGWTSKKSEC PLCRAFSSPS
KIILLR
