ID   PEX12_BOVIN             Reviewed;         359 AA.
AC   A4FUD4;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Peroxisome assembly protein 12;
DE   AltName: Full=Peroxin-12;
GN   Name=PEX12;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for protein import into peroxisomes. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PEX5 and PEX10. Interacts with PEX19 via its
CC       cytoplasmic domain (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; BC114718; AAI14719.1; -; mRNA.
DR   RefSeq; XP_010796495.1; XM_010798193.2.
DR   RefSeq; XP_010814094.1; XM_010815792.2.
DR   AlphaFoldDB; A4FUD4; -.
DR   STRING; 9913.ENSBTAP00000026285; -.
DR   PaxDb; A4FUD4; -.
DR   PRIDE; A4FUD4; -.
DR   Ensembl; ENSBTAT00000026285; ENSBTAP00000026285; ENSBTAG00000019723.
DR   GeneID; 506007; -.
DR   KEGG; bta:506007; -.
DR   CTD; 5193; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019723; -.
DR   VGNC; VGNC:32754; PEX12.
DR   eggNOG; KOG0826; Eukaryota.
DR   GeneTree; ENSGT00390000016209; -.
DR   HOGENOM; CLU_031067_1_0_1; -.
DR   InParanoid; A4FUD4; -.
DR   OMA; NPAIIET; -.
DR   OrthoDB; 1204472at2759; -.
DR   TreeFam; TF314511; -.
DR   Reactome; R-BTA-9603798; Class I peroxisomal membrane protein import.
DR   Proteomes; UP000009136; Chromosome 19.
DR   Bgee; ENSBTAG00000019723; Expressed in semen and 107 other tissues.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:Ensembl.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
DR   GO; GO:0007031; P:peroxisome organization; ISS:UniProtKB.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   GO; GO:0006513; P:protein monoubiquitination; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017375; PEX12.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12888; PTHR12888; 1.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Metal-binding; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..359
FT                   /note="Peroxisome assembly protein 12"
FT                   /id="PRO_0000356190"
FT   TOPO_DOM        1..158
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        180..239
FT                   /note="Peroxisomal matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..359
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         304..343
FT                   /note="RING-type; degenerate"
SQ   SEQUENCE   359 AA;  40766 MW;  F226003755C8E3C9 CRC64;
     MAEHGAHITT ASVVDDQPSI FEVVAQDSLM SAVRPALQHV VKVLAESNPA HFGFFWRWFD
     EIFTLLDLLL QQHYLSKTSA SFSENFYGLK RIVMGDQHKL QRLANAGLPK QQFMKSIMFL
     VLLPYLKVKL EKLVSSLREE DEYSIHPPSS RWKRFYRAFL AAYPFVNMAW EGWFLVQQLR
     YILGKAQHHS PLLRLAGVRL GRLTVQDIQA LEHKPAEASM MQLPAGSIGE KIKSALKKAV
     GGVALSLSTG LSVGVFFLQF LEWWYSSENQ ETIKSLTALP TPPPPVHLDY NSDSPLLPKM
     KTVCPLCRKN RVNDTVLATS GYVFCYRCVF HYVRSHQACP ITGYPTEVQH LIKLYSPEN