ID   PEX12_CAEEL             Reviewed;         359 AA.
AC   Q19189;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Putative peroxisome assembly protein 12;
DE   AltName: Full=Peroxin-12;
GN   Name=prx-12; ORFNames=F08B12.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Required for protein import into peroxisomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Single-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; Z68104; CAA92113.1; -; Genomic_DNA.
DR   PIR; T20575; T20575.
DR   RefSeq; NP_001309444.1; NM_001322631.1.
DR   AlphaFoldDB; Q19189; -.
DR   BioGRID; 46240; 13.
DR   DIP; DIP-25513N; -.
DR   STRING; 6239.F08B12.2; -.
DR   EPD; Q19189; -.
DR   PaxDb; Q19189; -.
DR   PeptideAtlas; Q19189; -.
DR   EnsemblMetazoa; F08B12.2.1; F08B12.2.1; WBGene00004197.
DR   GeneID; 181331; -.
DR   KEGG; cel:CELE_F08B12.2; -.
DR   UCSC; F08B12.2; c. elegans.
DR   CTD; 181331; -.
DR   WormBase; F08B12.2; CE51466; WBGene00004197; prx-12.
DR   eggNOG; KOG0826; Eukaryota.
DR   GeneTree; ENSGT00390000016209; -.
DR   HOGENOM; CLU_031067_1_0_1; -.
DR   InParanoid; Q19189; -.
DR   OMA; NPAIIET; -.
DR   OrthoDB; 1204472at2759; -.
DR   PhylomeDB; Q19189; -.
DR   Reactome; R-CEL-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-CEL-9033241; Peroxisomal protein import.
DR   Reactome; R-CEL-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:Q19189; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00004197; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   GO; GO:0007031; P:peroxisome organization; IMP:WormBase.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   GO; GO:0006513; P:protein monoubiquitination; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017375; PEX12.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12888; PTHR12888; 1.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
DR   SMART; SM00184; RING; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Peroxisome; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc-finger.
FT   CHAIN           1..359
FT                   /note="Putative peroxisome assembly protein 12"
FT                   /id="PRO_0000218613"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         307..346
FT                   /note="RING-type; degenerate"
SQ   SEQUENCE   359 AA;  41289 MW;  639057240A1BA93C CRC64;
     MSTTIRASQL ASSISPKTEE KQPSVFDIIA QENLATSIRP ALQHLVKYLA FFKPKTFLSV
     HRNFDEYYII FDLILQNHYL RNYGASFTEN FYSMKRIASG TGNPPNDGRE RIMSLITLVG
     WPYVENKLNQ LYDRLKEVYE CRSWSSINGM KAKCQKMFVI IWPYIKTALK AVKSALQLAY
     ILNRSSIHSP WLYFSGVILK HLTPEDLEAF NAVPLHLQTG YQISRGTLNE HIHLRFFNRI
     WRFILGLPGI VSRLFAYGLF FVQFLDYMYN TDLAKLTKTG LDGAIPSPPH KMIISESEIL
     SLDTNKCPIC LKKRVNDTAL FVSGYVFCYT CINQYVNTYN KCPVTGCPAN VQHLIRLFV