ID   PEX12_EMENI             Reviewed;         489 AA.
AC   C8VCP8; Q5AWM4;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Peroxisome assembly protein 12;
DE   AltName: Full=Peroxin-12;
GN   Name=PEX12; ORFNames=AN10925;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: Required for protein import into peroxisomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA61357.1; Type=Erroneous gene model prediction; Note=AN7306 was demerged into AN10923 and AN10925.; Evidence={ECO:0000305};
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DR   EMBL; BN001304; CBF78652.1; -; Genomic_DNA.
DR   EMBL; AACD01000127; EAA61357.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_680575.1; XM_675483.1.
DR   AlphaFoldDB; C8VCP8; -.
DR   STRING; 162425.CADANIAP00000130; -.
DR   EnsemblFungi; CBF78652; CBF78652; ANIA_10925.
DR   EnsemblFungi; EAA61357; EAA61357; AN7306.2.
DR   GeneID; 2869845; -.
DR   KEGG; ani:AN7306.2; -.
DR   VEuPathDB; FungiDB:AN10925; -.
DR   eggNOG; KOG0826; Eukaryota.
DR   HOGENOM; CLU_272850_0_0_1; -.
DR   InParanoid; C8VCP8; -.
DR   OMA; NPAIIET; -.
DR   OrthoDB; 245234at2759; -.
DR   Proteomes; UP000000560; Chromosome IV.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; ISO:AspGD.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; ISO:AspGD.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; ISO:AspGD.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017375; PEX12.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12888; PTHR12888; 1.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   SMART; SM00184; RING; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Peroxisome; Protein transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Zinc; Zinc-finger.
FT   CHAIN           1..489
FT                   /note="Peroxisome assembly protein 12"
FT                   /id="PRO_0000404498"
FT   TRANSMEM        188..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        280..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         384..444
FT                   /note="RING-type; degenerate"
FT   REGION          316..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          433..469
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        330..344
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..466
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   489 AA;  55134 MW;  9EDA5B383CBBE642 CRC64;
     MEYLPSLQQE FDELKPSLFE LLAEQQLSDL LPPSIRYILA VATHRHPRYL LRVLNSFDEV
     YALLSLVVER YYLRNFGGSF TENFYSLKRE RVLLTKNGEI PRAQLGAPGP VRESLKLRNS
     DVWKNLLVMV GIPYLKRKLD EGYDIHAAPQ ASLIMNGGPR YNPSDDLPPH PTIRQRFMHA
     YKWFLRNVYP SFNAAYYFSI LAFNLAYLFD NTKYSSPFLW LIGTRIRRLS SADHQAIAKI
     LEGKPQTPNS RSARSRPGSG LLGLFSPHNL YPQLLTSLRY FLPASIFALK FLEWWHASDF
     SRQLARKATD TLDIPAPITK GMISPSERKS RPPTKQKEDP ESPKSALKTS SPHKRIQPPI
     SASSYLPIFT VPLPPADSDA ASSCPVCLNQ LTNPTACQTG YVYCYVCIFH WLNGEHQRQI
     DFMNGDGAGA AWEDDSGDGI DADGDRNETE SAAKTGKSRH GKWESGKGRC PVTGRRVLGG
     TEGLRRVLI