PEX12_MOUSE
ID PEX12_MOUSE Reviewed; 359 AA.
AC Q8VC48;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Peroxisome assembly protein 12;
DE AltName: Full=Peroxin-12;
GN Name=Pex12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Required for protein import into peroxisomes.
CC -!- SUBUNIT: Interacts with PEX5 and PEX10. Interacts with PEX19 via its
CC cytoplasmic domain (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC021800; AAH21800.1; -; mRNA.
DR CCDS; CCDS25160.1; -.
DR RefSeq; NP_598786.1; NM_134025.3.
DR RefSeq; XP_006531976.1; XM_006531913.1.
DR RefSeq; XP_006531977.1; XM_006531914.2.
DR RefSeq; XP_006531978.1; XM_006531915.2.
DR AlphaFoldDB; Q8VC48; -.
DR BioGRID; 222151; 1.
DR STRING; 10090.ENSMUSP00000018877; -.
DR PhosphoSitePlus; Q8VC48; -.
DR MaxQB; Q8VC48; -.
DR PaxDb; Q8VC48; -.
DR PRIDE; Q8VC48; -.
DR ProteomicsDB; 288097; -.
DR Antibodypedia; 27495; 129 antibodies from 26 providers.
DR DNASU; 103737; -.
DR Ensembl; ENSMUST00000018877; ENSMUSP00000018877; ENSMUSG00000018733.
DR Ensembl; ENSMUST00000108146; ENSMUSP00000103781; ENSMUSG00000018733.
DR Ensembl; ENSMUST00000175741; ENSMUSP00000135145; ENSMUSG00000018733.
DR Ensembl; ENSMUST00000176518; ENSMUSP00000135632; ENSMUSG00000018733.
DR GeneID; 103737; -.
DR KEGG; mmu:103737; -.
DR UCSC; uc007kon.1; mouse.
DR CTD; 5193; -.
DR MGI; MGI:2144177; Pex12.
DR VEuPathDB; HostDB:ENSMUSG00000018733; -.
DR eggNOG; KOG0826; Eukaryota.
DR GeneTree; ENSGT00390000016209; -.
DR HOGENOM; CLU_031067_1_0_1; -.
DR InParanoid; Q8VC48; -.
DR OMA; NPAIIET; -.
DR OrthoDB; 1204472at2759; -.
DR PhylomeDB; Q8VC48; -.
DR TreeFam; TF314511; -.
DR Reactome; R-MMU-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-MMU-9033241; Peroxisomal protein import.
DR Reactome; R-MMU-9603798; Class I peroxisomal membrane protein import.
DR BioGRID-ORCS; 103737; 12 hits in 74 CRISPR screens.
DR ChiTaRS; Pex12; mouse.
DR PRO; PR:Q8VC48; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8VC48; protein.
DR Bgee; ENSMUSG00000018733; Expressed in secondary oocyte and 243 other tissues.
DR ExpressionAtlas; Q8VC48; baseline and differential.
DR Genevisible; Q8VC48; MM.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; ISO:MGI.
DR GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:MGI.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; ISO:MGI.
DR GO; GO:0007031; P:peroxisome organization; ISO:MGI.
DR GO; GO:0016558; P:protein import into peroxisome matrix; ISO:MGI.
DR GO; GO:0006513; P:protein monoubiquitination; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR017375; PEX12.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12888; PTHR12888; 1.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR PIRSF; PIRSF038074; Peroxisome_assembly_p12; 1.
PE 1: Evidence at protein level;
KW Membrane; Metal-binding; Peroxisome; Protein transport; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport; Zinc; Zinc-finger.
FT CHAIN 1..359
FT /note="Peroxisome assembly protein 12"
FT /id="PRO_0000218611"
FT TOPO_DOM 1..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..239
FT /note="Peroxisomal matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..359
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT ZN_FING 304..343
FT /note="RING-type; degenerate"
SQ SEQUENCE 359 AA; 40633 MW; 20FABDFC806E9315 CRC64;
MAEYGAHITT ASVADDQPSI FEVVAQDSLM TAVRPALQHV VKVLAESNPA HYGFLWRWFD
EIFTLLDFLL QQHYLSRTSA SFSEHFYGLK RIVAGSSPHL QRPASAGLPK EHLWKSAMFL
VLLPYLKVKL EKLASSLREE DEYSIHPPSS RWKRFYRAFL AAYPFVNMAW EGWFLTQQLR
YILGKAEHHS PLLKLAGVRL ARLTAQDMQA IKQRLVEASA MQEPVRSVGE KIKSALKKAV
GGVALSLSTG LSVGVFFLQF LDWWYSSENQ EAIKSLTALP TPPPPVHLDY NSDSPLLPKM
KTVCPLCRKT RVNDTVLATS GYVFCYRCVF NYVRSHQACP ITGYPTEVQH LIKLYSPEN
