ID   PEX12_SCHPO             Reviewed;         343 AA.
AC   Q8TFH8;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Peroxisome assembly protein 12;
DE   AltName: Full=Peroxin-12;
GN   Name=pex12; ORFNames=SPAPB17E12.03;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Required for protein import into peroxisomes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAD27496.2; -; Genomic_DNA.
DR   RefSeq; NP_001018219.2; NM_001018699.3.
DR   AlphaFoldDB; Q8TFH8; -.
DR   SMR; Q8TFH8; -.
DR   BioGRID; 280485; 1.
DR   STRING; 4896.SPAPB17E12.03.1; -.
DR   MaxQB; Q8TFH8; -.
DR   PaxDb; Q8TFH8; -.
DR   EnsemblFungi; SPAPB17E12.03.1; SPAPB17E12.03.1:pep; SPAPB17E12.03.
DR   PomBase; SPAPB17E12.03; pex12.
DR   VEuPathDB; FungiDB:SPAPB17E12.03; -.
DR   eggNOG; KOG0826; Eukaryota.
DR   HOGENOM; CLU_031067_0_0_1; -.
DR   InParanoid; Q8TFH8; -.
DR   OMA; NPAIIET; -.
DR   PhylomeDB; Q8TFH8; -.
DR   Reactome; R-SPO-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-SPO-9033241; Peroxisomal protein import.
DR   Reactome; R-SPO-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:Q8TFH8; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; IEA:InterPro.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; ISM:PomBase.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; IBA:GO_Central.
DR   GO; GO:0070647; P:protein modification by small protein conjugation or removal; IC:PomBase.
DR   GO; GO:0006513; P:protein monoubiquitination; IBA:GO_Central.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR017375; PEX12.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12888; PTHR12888; 1.
DR   Pfam; PF04757; Pex2_Pex12; 1.
PE   3: Inferred from homology;
KW   Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT   CHAIN           1..343
FT                   /note="Peroxisome assembly protein 12"
FT                   /id="PRO_0000339876"
FT   ZN_FING         289..328
FT                   /note="RING-type; degenerate"
SQ   SEQUENCE   343 AA;  39960 MW;  2B7D45E46E15BF1D CRC64;
     MDSPSLLEVL QVQQVEKLIS PSLRFILAYF THRYPRFLLR AYNSFDGIYL LVKLLLEKSQ
     LKKWNATSVE RRFQLKRVIA VRDSSIIAEE FPQESESATS LNGIDVLKKL FLTYCIPYLL
     EKCESLTTVK ENHTAVSILS LQARDKQKGA LSVFYSKIKI LLVRLKKILH FVFRLIRKSN
     TYLQWLYYLL YALGKTPYTN LADHILRQRV IYNVENIHSR KLISTREKSS LLTSIADHSM
     EGFLIIIQLI DWWQSNNYES HLKKGEVAFT ELAPPKLPFE INVSTTDICK ICGEKIKNPA
     VLSTGFVFCY PCIQVWLQRH PFKCPVTNLE LSRKGESFWR LMI