ID   PEX13_DICDI             Reviewed;         570 AA.
AC   Q54CL3;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Probable peroxisomal membrane protein PEX13;
DE   AltName: Full=Peroxin-13;
GN   Name=pex13; ORFNames=DDB_G0292870;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May be a component of the peroxisomal translocation
CC       machinery. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxin-13 family. {ECO:0000305}.
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DR   EMBL; AAFI02000197; EAL60984.1; -; Genomic_DNA.
DR   RefSeq; XP_629403.1; XM_629401.1.
DR   AlphaFoldDB; Q54CL3; -.
DR   SMR; Q54CL3; -.
DR   STRING; 44689.DDB0238077; -.
DR   PaxDb; Q54CL3; -.
DR   EnsemblProtists; EAL60984; EAL60984; DDB_G0292870.
DR   GeneID; 8628922; -.
DR   KEGG; ddi:DDB_G0292870; -.
DR   dictyBase; DDB_G0292870; pex13.
DR   eggNOG; KOG3875; Eukaryota.
DR   HOGENOM; CLU_478550_0_0_1; -.
DR   InParanoid; Q54CL3; -.
DR   OMA; RTPMRPW; -.
DR   Reactome; R-DDI-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-DDI-9033241; Peroxisomal protein import.
DR   Reactome; R-DDI-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:Q54CL3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; ISS:dictyBase.
DR   GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0022607; P:cellular component assembly; IEA:UniProt.
DR   GO; GO:0016560; P:protein import into peroxisome matrix, docking; ISS:dictyBase.
DR   InterPro; IPR007223; Peroxin-13_N.
DR   InterPro; IPR035463; Pex13.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR19332; PTHR19332; 1.
DR   Pfam; PF04088; Peroxin-13_N; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF50044; SSF50044; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   3: Inferred from homology;
KW   Membrane; Peroxisome; Protein transport; Reference proteome; SH3 domain;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..570
FT                   /note="Probable peroxisomal membrane protein PEX13"
FT                   /id="PRO_0000371414"
FT   TOPO_DOM        1..348
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        349..369
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        370..570
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          393..452
FT                   /note="SH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT   REGION          1..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          453..570
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..67
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        453..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   570 AA;  60573 MW;  A886CAAE6CD7C735 CRC64;
     MRRSPPKPWE NNSGGGGSTS MTGSGGISRP MSGPQRTTSP GGGSSTTTQT STLNNTGSPS
     TSVGGPLVTR PRTPMRPWES GGAGSSSIDS FGGGVGGSSG YRSSYGGGYR DSYSSGGYGS
     SGYGSSYGSG GSGGYGSSLY GGGGYSSGGY GGSGYGSSYG GGYGSSYGSG YGSSYGGSGY
     GSSYGGGYGS SYGGGYGGGY GGGYGQRGYD NMDGKGGALQ SVVSSGHSWM EALHSIVDTF
     SRFSRLLDAN FDAVHGSFSS IIRLCQSMSH FSYEIMAIIK TYSLFRMFQS VASRFLRVFR
     YLLGKKSKSN SSNNNTSSKF GSNAITESLR QANMDVSDFR NFQNEKKQSV GTLILIIAAT
     FIGVPMVIGQ LLNLRRRGQA SRLDKGWEEQ QGGGYGQVKA IYEFNPETTR DLPLRVGDIV
     NVIDKPHDNW WVGECNGLSG FFPVDFTEKI SPNDINNNNN NNNNNNNNIN TSVQIYDNNN
     GFNRNNSNNN LNNSEYSDYS SSNNNNNNNN NNNNNSNYQL QSNFSSNNDG ISKNIIYNNN
     NDNQRPISPS KTSQQLSRSE LMDKPYVEES