ID   PEX14_PICAN             Reviewed;         351 AA.
AC   P78723;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Peroxisomal membrane protein PEX14 {ECO:0000305};
DE   AltName: Full=Peroxin-14;
DE   AltName: Full=Peroxisomal membrane protein PER10;
GN   Name=PEX14; Synonyms=PER10;
OS   Pichia angusta (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=870730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 34438 / CBS 4732 / DSM 70277 / JCM 3621 / NBRC 1476 / NRRL
RC   Y-5445;
RX   PubMed=9009266; DOI=10.1093/emboj/16.1.44;
RA   Komori M., Rasmussen S.W., Kiel J.A.K.W., Baerends R.J.S., Cregg J.M.,
RA   van der Klei I.J., Veenhuis M.;
RT   "The Hansenula polymorpha PEX14 gene encodes a novel peroxisomal membrane
RT   protein essential for peroxisome biogenesis.";
RL   EMBO J. 16:44-53(1997).
CC   -!- FUNCTION: Component of the peroxisomal translocation machinery with
CC       PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the SH3 domain of PEX13. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Peripheral membrane protein;
CC       Cytoplasmic side.
CC   -!- SIMILARITY: Belongs to the peroxin-14 family. {ECO:0000305}.
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DR   EMBL; U46195; AAB40596.1; -; Genomic_DNA.
DR   AlphaFoldDB; P78723; -.
DR   SMR; P78723; -.
DR   ELM; P78723; -.
DR   PhylomeDB; P78723; -.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016560; P:protein import into peroxisome matrix, docking; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR025655; PEX14.
DR   InterPro; IPR006785; Pex14_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23058; PTHR23058; 1.
DR   Pfam; PF04695; Pex14_N; 1.
PE   3: Inferred from homology;
KW   Membrane; Peroxisome; Protein transport; Translocation; Transport.
FT   CHAIN           1..351
FT                   /note="Peroxisomal membrane protein PEX14"
FT                   /id="PRO_0000058327"
FT   REGION          54..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          243..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           83..91
FT                   /note="SH3-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        243..261
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        282..310
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        316..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   351 AA;  39034 MW;  BC97D914894BC03D CRC64;
     MSQQPATTSR AELVSSAVEF LLDQSIADSP LAKKVEFLES KGLTQQEIEE ALQKARTGTV
     QASPSQQSVV PPRPPVPDYY PSAPPLPERD WKDYFIMATA TAGISYGVYQ FVKRYVVPKI
     LPPSKTQLEQ DKAAIDHEFQ RVESLLEKFE ADQKEFYQKQ EAKSKKIDET LQEVDEIINK
     TNEKNLNNEE TLKYLKLEIE NIKTTLLKTL DSQKATLNAE LSAMEKQLQD IKFDIKTSGI
     AVAPQLSTPP SESTSRQSPA AEAKPKINLN IPPTTSIPSL RDVLSREKDK DVNSDSIAQY
     EQRTANEKDV ERSIPAWQLS ASNGGSSTTS GVAGDEQKEP KRGIPAWQLN A