PEX14_SCHPO
ID PEX14_SCHPO Reviewed; 286 AA.
AC O60065;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Peroxisomal membrane protein pex14 {ECO:0000305};
DE AltName: Full=Peroxin-14 {ECO:0000305};
GN Name=pex14; ORFNames=SPBC13G1.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the peroxisomal translocation machinery with
CC pex13 and pex17. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000269|PubMed:16823372}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16823372}; Cytoplasmic side
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the peroxin-14 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA18656.1; -; Genomic_DNA.
DR PIR; T39404; T39404.
DR RefSeq; NP_596552.1; NM_001022473.2.
DR AlphaFoldDB; O60065; -.
DR SMR; O60065; -.
DR BioGRID; 276617; 4.
DR IntAct; O60065; 1.
DR STRING; 4896.SPBC13G1.03c.1; -.
DR iPTMnet; O60065; -.
DR MaxQB; O60065; -.
DR PaxDb; O60065; -.
DR PRIDE; O60065; -.
DR EnsemblFungi; SPBC13G1.03c.1; SPBC13G1.03c.1:pep; SPBC13G1.03c.
DR GeneID; 2540079; -.
DR KEGG; spo:SPBC13G1.03c; -.
DR PomBase; SPBC13G1.03c; pex14.
DR VEuPathDB; FungiDB:SPBC13G1.03c; -.
DR eggNOG; KOG2629; Eukaryota.
DR HOGENOM; CLU_045718_1_0_1; -.
DR InParanoid; O60065; -.
DR OMA; RRDWRDW; -.
DR PhylomeDB; O60065; -.
DR Reactome; R-SPO-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR Reactome; R-SPO-9033241; Peroxisomal protein import.
DR Reactome; R-SPO-9603798; Class I peroxisomal membrane protein import.
DR PRO; PR:O60065; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:1990429; C:peroxisomal importomer complex; IBA:GO_Central.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:PomBase.
DR GO; GO:0005777; C:peroxisome; IDA:PomBase.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IBA:GO_Central.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR025655; PEX14.
DR InterPro; IPR006785; Pex14_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR23058; PTHR23058; 1.
DR Pfam; PF04695; Pex14_N; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Peroxisome; Protein transport; Reference proteome;
KW Translocation; Transport.
FT CHAIN 1..286
FT /note="Peroxisomal membrane protein pex14"
FT /id="PRO_0000372384"
FT REGION 218..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 122..214
FT /evidence="ECO:0000255"
FT MOTIF 61..69
FT /note="SH3-binding"
FT /evidence="ECO:0000250"
FT COMPBIAS 219..239
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 286 AA; 32814 MW; 26A73B1A935E6D77 CRC64;
MREDLLRNSV EFLREKTVLD APDVKKIEFL KSKGLTAEEI QEAFKLAKNP LFPSYPRFEN
TSNFVSRDWR DWFIMGVIST GFAWSAYSLV KKYIAPMFRA PSQNAYEADK NALDAKFLEA
HKILENLDEQ TRKLSERTEK QQDELDIALD DLEETLNTLK RTSENRDREI ARISQDVYTM
STITLPQSLE QIKKSQEEAL QNLSREISSL RCLQTDSKKD DTFATTSNSS IPVLENPLDT
SEGFQTKKVG TASLPDWQIS MHNEASKNID FNDIDPAESY VAEDAY
