ID   PEX16_BOVIN             Reviewed;         328 AA.
AC   Q2KII7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Peroxisomal membrane protein PEX16;
DE   AltName: Full=Peroxin-16;
DE   AltName: Full=Peroxisomal biogenesis factor 16;
GN   Name=PEX16;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for peroxisome membrane biogenesis. May play a role
CC       in early stages of peroxisome assembly. Can recruit other peroxisomal
CC       proteins, such as PEX3 and PMP34, to de novo peroxisomes derived from
CC       the endoplasmic reticulum (ER). May function as receptor for PEX3 (By
CC       similarity). {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SUBUNIT: Interacts with PEX19. {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q2KII7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q2KII7-2; Sequence=VSP_036594;
CC   -!- SIMILARITY: Belongs to the peroxin-16 family. {ECO:0000305}.
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DR   EMBL; AAFC03090303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC112623; AAI12624.1; -; mRNA.
DR   RefSeq; NP_001068917.1; NM_001075449.2. [Q2KII7-2]
DR   RefSeq; XP_005216504.1; XM_005216447.3. [Q2KII7-1]
DR   AlphaFoldDB; Q2KII7; -.
DR   STRING; 9913.ENSBTAP00000004065; -.
DR   PaxDb; Q2KII7; -.
DR   PRIDE; Q2KII7; -.
DR   Ensembl; ENSBTAT00000004065; ENSBTAP00000004065; ENSBTAG00000003126. [Q2KII7-1]
DR   GeneID; 510447; -.
DR   KEGG; bta:510447; -.
DR   CTD; 9409; -.
DR   VEuPathDB; HostDB:ENSBTAG00000003126; -.
DR   eggNOG; KOG4546; Eukaryota.
DR   GeneTree; ENSGT00390000017790; -.
DR   HOGENOM; CLU_070601_0_0_1; -.
DR   InParanoid; Q2KII7; -.
DR   OrthoDB; 908842at2759; -.
DR   TreeFam; TF324139; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000003126; Expressed in retina and 105 other tissues.
DR   ExpressionAtlas; Q2KII7; baseline.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; ISS:UniProtKB.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; ISS:UniProtKB.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
DR   GO; GO:0032581; P:ER-dependent peroxisome organization; ISS:UniProtKB.
DR   GO; GO:0016557; P:peroxisome membrane biogenesis; ISS:UniProtKB.
DR   GO; GO:0007031; P:peroxisome organization; ISS:UniProtKB.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; ISS:UniProtKB.
DR   GO; GO:0006625; P:protein targeting to peroxisome; ISS:UniProtKB.
DR   InterPro; IPR013919; Pex16.
DR   PANTHER; PTHR13299; PTHR13299; 1.
DR   Pfam; PF08610; Pex16; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Peroxisome; Peroxisome biogenesis;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Peroxisomal membrane protein PEX16"
FT                   /id="PRO_0000366960"
FT   TOPO_DOM        1..84
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..110
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          66..81
FT                   /note="Required for peroxisomal location"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5Y5"
FT   REGION          149..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..328
FT                   /note="Interaction with PEX19"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5Y5"
FT   COMPBIAS        154..169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         121..146
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.2"
FT                   /id="VSP_036594"
SQ   SEQUENCE   328 AA;  37574 MW;  9B6347E9CEE4D49D CRC64;
     MEKLRLLGLR YQEYVTRHPA ATAQLETAVR GLSYLLAGRF ADSHELSELV YSASNLLVLL
     NDGILRKELR KKLPMSLSQQ RLLTWLSVLE CVEVFMEMGA TKVWGEVGRW LVIALIQLAK
     AVLRMFLLIW FKAGLQTSPP IVPLDREIQA QSRDGDHSSG SQEQSYVGKR SNRVVRTLQN
     TPSLHSRHWG APQQREELGV APTPLGLQET IAESLHIARP LLHLLSLGLW GQRSWTPWLL
     SGVVDVTSLS LLSDRKGLTR RERLELRRRT ILLLYYLLRS PFYDRFSEAK ILFLLQLLAD
     HVPGIGLVTR PLMDYLPNWQ KIYFYSWG