ID   PEX16_DANRE             Reviewed;         335 AA.
AC   Q4QRH7;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Peroxisomal membrane protein PEX16;
DE   AltName: Full=Peroxin-16;
DE   AltName: Full=Peroxisomal biogenesis factor 16;
GN   Name=pex16; ORFNames=zgc:112248;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peroxisome biogenesis.
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SIMILARITY: Belongs to the peroxin-16 family. {ECO:0000305}.
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DR   EMBL; BC096874; AAH96874.1; -; mRNA.
DR   RefSeq; NP_001020340.1; NM_001025169.1.
DR   AlphaFoldDB; Q4QRH7; -.
DR   STRING; 7955.ENSDARP00000075468; -.
DR   PaxDb; Q4QRH7; -.
DR   GeneID; 573990; -.
DR   KEGG; dre:573990; -.
DR   CTD; 9409; -.
DR   ZFIN; ZDB-GENE-050626-49; pex16.
DR   eggNOG; KOG4546; Eukaryota.
DR   InParanoid; Q4QRH7; -.
DR   OrthoDB; 908842at2759; -.
DR   PhylomeDB; Q4QRH7; -.
DR   Reactome; R-DRE-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:Q4QRH7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR   InterPro; IPR013919; Pex16.
DR   PANTHER; PTHR13299; PTHR13299; 1.
DR   Pfam; PF08610; Pex16; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..335
FT                   /note="Peroxisomal membrane protein PEX16"
FT                   /id="PRO_0000366962"
FT   TOPO_DOM        1..80
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        102..109
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..335
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          66..81
FT                   /note="Required for peroxisomal location"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5Y5"
FT   REGION          146..168
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  38555 MW;  6CBA7852A792E7F2 CRC64;
     MEKLTRVFER YQEYVRTSPA AASHLESTVR ALSYLIAGRF SDSHEISELV YSASNLLVLL
     NDGILRKNLS RTLPMSISQQ KLLTWLSVLE YVEVFVEMAA AKMWGDAGRW LVIVLIQIAK
     AVLRCLLLFW YKSGIQTSPP IIPLDRDSQL CSQDNNEEED DEDSSFVGQR SGRVVRPLGS
     APSLQSRLWG LPRKKKVSRN QEEELHSSPT PLGLQETIAE SLYIARPLLH LASLGICGKR
     SWKPWILSGL LEITSFSLLS DMKALNRRER AEMRRRAFLL LYYLLRSPFY DRYSETKILF
     LLRFLADYVP GVGLVARPLM EYLPIWQKIY FYNWG