PEX16_SCHPO
ID PEX16_SCHPO Reviewed; 364 AA.
AC O94516;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Peroxisomal membrane protein PEX16;
DE Short=Peroxin-16;
GN Name=pex16; ORFNames=SPBC646.15c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Involved in the biogenesis of peroxisomes. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Peripheral membrane protein;
CC Matrix side.
CC -!- SIMILARITY: Belongs to the peroxin-16 family. {ECO:0000305}.
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DR EMBL; CU329671; CAA22819.2; -; Genomic_DNA.
DR PIR; T40591; T40591.
DR RefSeq; NP_595373.2; NM_001021281.2.
DR AlphaFoldDB; O94516; -.
DR BioGRID; 277578; 1.
DR STRING; 4896.SPBC646.15c.1; -.
DR iPTMnet; O94516; -.
DR MaxQB; O94516; -.
DR PaxDb; O94516; -.
DR PRIDE; O94516; -.
DR EnsemblFungi; SPBC646.15c.1; SPBC646.15c.1:pep; SPBC646.15c.
DR GeneID; 2541063; -.
DR KEGG; spo:SPBC646.15c; -.
DR PomBase; SPBC646.15c; pex16.
DR VEuPathDB; FungiDB:SPBC646.15c; -.
DR eggNOG; KOG4546; Eukaryota.
DR HOGENOM; CLU_761077_0_0_1; -.
DR InParanoid; O94516; -.
DR OMA; FINIYAT; -.
DR Reactome; R-SPO-9603798; Class I peroxisomal membrane protein import.
DR PRO; PR:O94516; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005778; C:peroxisomal membrane; ISS:PomBase.
DR GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR GO; GO:0016558; P:protein import into peroxisome matrix; ISS:PomBase.
DR GO; GO:0045046; P:protein import into peroxisome membrane; ISS:PomBase.
DR InterPro; IPR013919; Pex16.
DR PANTHER; PTHR13299; PTHR13299; 1.
DR Pfam; PF08610; Pex16; 1.
PE 1: Evidence at protein level;
KW Membrane; Peroxisome; Peroxisome biogenesis; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..364
FT /note="Peroxisomal membrane protein PEX16"
FT /id="PRO_0000374020"
FT MOD_RES 200
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 364 AA; 43105 MW; E4610FDBEE4681D7 CRC64;
MKPLAYYEDQ LLKDEKSFLK VTEIERLLSY AAYLLPAEFR DDQLKSQTIT SILLLLHQFH
TGLLFRKIAE LPKTEQAILK SERTQYLEYF RKKNPSFEKV SELLYFLNIS TFPIELVISK
YNPSRQYDSV LFLESVKFLL RVHIMWTTGG DLPLSNPVLQ RDFNVKTFIH LHKKYSNSGS
AVVLKNSKKV VPRLNTVNSS LDFLQNRTPR LSSILPDEIF TKRLPNLRIF SNFIKVCRPL
IYMLFMWHWK RKQKSSSLKV RPWGPWIVAF VFEVISQLID RRCESATSSR QGFGLERRTN
QSQFQHFVVW AFTQGRFYDE FTKHWINRSL SWVNSIPVFG KYLLLSVEER QKSLENYISS
VRNY
