ID   PEX16_XENLA             Reviewed;         340 AA.
AC   Q6INN0;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Peroxisomal membrane protein PEX16;
DE   AltName: Full=Peroxin-16;
DE   AltName: Full=Peroxisomal biogenesis factor 16;
GN   Name=pex16;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peroxisome biogenesis.
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SIMILARITY: Belongs to the peroxin-16 family. {ECO:0000305}.
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DR   EMBL; BC072248; AAH72248.1; -; mRNA.
DR   RefSeq; NP_001085197.1; NM_001091728.1.
DR   AlphaFoldDB; Q6INN0; -.
DR   DNASU; 432288; -.
DR   GeneID; 432288; -.
DR   KEGG; xla:432288; -.
DR   CTD; 432288; -.
DR   Xenbase; XB-GENE-1011470; pex16.S.
DR   OrthoDB; 908842at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 432288; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   InterPro; IPR013919; Pex16.
DR   PANTHER; PTHR13299; PTHR13299; 1.
DR   Pfam; PF08610; Pex16; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..340
FT                   /note="Peroxisomal membrane protein PEX16"
FT                   /id="PRO_0000366963"
FT   TOPO_DOM        1..89
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..114
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..340
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          71..86
FT                   /note="Required for peroxisomal location"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5Y5"
FT   REGION          196..215
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  38943 MW;  DC95B613F6E777F6 CRC64;
     MAARYWDKLR DLSQKYKEYV IQNPTGATQL ESGVRMLSYL IAGRFADSHE LSELVYSSSN
     LLALLNDGIL RKELLTPPPT EGSRRRLLTW LGVLESLEVF IEIGAARAWG ERSRWAAILI
     IQLLKACLRI VLLFWYRVGI QSSPPVTPLD REGILNQAED NSKSSSSCFV GRRSSRAVRS
     LNDSASSHRR FWRSPQIHEG KQQKNGETEN DKEGSELGTL GTLAEAIHIL RPITHLLSLA
     ACGQKSWKPW MMAAALDITS ISLLSDVRNL SRRERIELRR RMFLLLYYLL RSPFYNNYTE
     TRLLLLLRLL GDYVPGLGLV ARPLMDYLPV WQKIYFYNWG