ID   PEX16_XENTR             Reviewed;         340 AA.
AC   B0JYZ2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Peroxisomal membrane protein PEX16;
DE   AltName: Full=Peroxin-16;
DE   AltName: Full=Peroxisomal biogenesis factor 16;
GN   Name=pex16;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peroxisome biogenesis.
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y5Y5}.
CC   -!- SIMILARITY: Belongs to the peroxin-16 family. {ECO:0000305}.
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DR   EMBL; BC158973; AAI58974.1; -; mRNA.
DR   RefSeq; NP_001120111.1; NM_001126639.1.
DR   AlphaFoldDB; B0JYZ2; -.
DR   GeneID; 100145130; -.
DR   KEGG; xtr:100145130; -.
DR   CTD; 9409; -.
DR   Xenbase; XB-GENE-1011467; pex16.
DR   InParanoid; B0JYZ2; -.
DR   OrthoDB; 908842at2759; -.
DR   Reactome; R-XTR-9603798; Class I peroxisomal membrane protein import.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0007031; P:peroxisome organization; IBA:GO_Central.
DR   InterPro; IPR013919; Pex16.
DR   PANTHER; PTHR13299; PTHR13299; 1.
DR   Pfam; PF08610; Pex16; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..340
FT                   /note="Peroxisomal membrane protein PEX16"
FT                   /id="PRO_0000366964"
FT   TOPO_DOM        1..89
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        111..114
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..340
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          71..86
FT                   /note="Required for peroxisomal location"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y5Y5"
FT   REGION          196..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..214
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   340 AA;  38773 MW;  8FA2BD67FCD96D93 CRC64;
     MAARYWDKLQ DLSQKYKDYV IQNPTGATQL ESAVRMLSYL IAGRFADSHE LSELVYSASN
     LLALLNDGIL RKELLAPPPT EGSRRRLLTW LGVLESLEVF IEIGAARAWG DRTRWAAILI
     IQLLKACLRI VLLFWYRAGI QSSPPVTPLD REGILNQAED NSNSGSSCFV GRRSSRAVRS
     LDDSASSHRR FWRSPQIHDG KQRNTGETES DKDGSELGTL GTLAEAIHIL RPITHLLSLA
     TWGQKSWKPW MVAAALDITS ISLLSDVRNL SHRERAELRR RMFLLLYYLL RSPFYNHYTE
     TRLLLLLRLL GDYVPGVGLV ARPLMDYLPV WQKIYFYNWG