PEX17_YEAST
ID PEX17_YEAST Reviewed; 199 AA.
AC P40155; D6W0X6;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Peroxisomal membrane protein PEX17;
DE AltName: Full=Peroxin-17;
GN Name=PEX17; Synonyms=PAS9; OrderedLocusNames=YNL214W; ORFNames=N1319;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=7762305; DOI=10.1002/yea.320110111;
RA Coster F., van Dyck L., Jonniaux J.-L., Purnelle B., Goffeau A.;
RT "The sequence of a 13.5 kb DNA segment from the left arm of yeast
RT chromosome XIV reveals MER1; RAP1; a new putative member of the DNA
RT replication complex and a new putative serine/threonine phosphatase gene.";
RL Yeast 11:85-91(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP CHARACTERIZATION.
RX PubMed=9425153; DOI=10.1083/jcb.140.1.49;
RA Huhse B., Rehling P., Albertini M., Blank L., Meller K., Kunau W.-H.;
RT "Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the
RT peroxisomal protein translocation machinery.";
RL J. Cell Biol. 140:49-60(1998).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Component of the peroxisomal translocation machinery with
CC PEX13 and PEX14. Interacts indirectly with the PTS1 receptor
CC (PAS10/PEX5) and directly binds to PEX14. Required for import of both
CC PTS1 and PTS2 proteins.
CC -!- INTERACTION:
CC P40155; P53112: PEX14; NbExp=14; IntAct=EBI-13218, EBI-13212;
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Peripheral membrane protein;
CC Cytoplasmic side.
CC -!- MISCELLANEOUS: Present with 656 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X78898; CAA55494.1; -; Genomic_DNA.
DR EMBL; Z71490; CAA96116.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10342.1; -; Genomic_DNA.
DR PIR; S50717; S50717.
DR RefSeq; NP_014185.1; NM_001183052.1.
DR AlphaFoldDB; P40155; -.
DR SMR; P40155; -.
DR BioGRID; 35622; 99.
DR ComplexPortal; CPX-1904; Peroxisomal PEX13-PEX14-PEX17 docking complex.
DR DIP; DIP-2474N; -.
DR IntAct; P40155; 10.
DR MINT; P40155; -.
DR STRING; 4932.YNL214W; -.
DR TCDB; 3.A.20.1.5; the peroxisomal protein importer (ppi) family.
DR PaxDb; P40155; -.
DR PRIDE; P40155; -.
DR EnsemblFungi; YNL214W_mRNA; YNL214W; YNL214W.
DR GeneID; 855507; -.
DR KEGG; sce:YNL214W; -.
DR SGD; S000005158; PEX17.
DR VEuPathDB; FungiDB:YNL214W; -.
DR eggNOG; ENOG502S4G6; Eukaryota.
DR HOGENOM; CLU_115007_0_0_1; -.
DR InParanoid; P40155; -.
DR OMA; REMKGWF; -.
DR BioCyc; YEAST:G3O-33220-MON; -.
DR PRO; PR:P40155; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P40155; protein.
DR GO; GO:1990429; C:peroxisomal importomer complex; IDA:SGD.
DR GO; GO:0005778; C:peroxisomal membrane; IDA:SGD.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; IPI:SGD.
PE 1: Evidence at protein level;
KW Membrane; Peroxisome; Protein transport; Reference proteome; Transport.
FT CHAIN 1..199
FT /note="Peroxisomal membrane protein PEX17"
FT /id="PRO_0000058333"
SQ SEQUENCE 199 AA; 23169 MW; A0D3641B23C63C4D CRC64;
MTSINSFPRN IDWPSNIGIK KIEGTNPTVN AIKGLLYNGG SIYAFLYFVI AMFVEPTLQK
QYQQRNDFSL FVLLRLRRII AQLQKRLVMT PVSSLGFNEQ NNFVERSTQT SDDNIIREDN
SHWAEMIYQL QNMKQELQYF NRSSGQPSES IDDFVFQIKM VTDQVELTDR SRAFSNKSRN
IIQGIREIKG WFVNGQVPR
