PEX19_BOVIN
ID PEX19_BOVIN Reviewed; 299 AA.
AC Q3SZD1;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Peroxisomal biogenesis factor 19;
DE AltName: Full=Peroxin-19;
DE AltName: Full=Peroxisomal farnesylated protein;
DE Flags: Precursor;
GN Name=PEX19; Synonyms=PXF;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a
CC cytosolic chaperone and as an import receptor for peroxisomal membrane
CC proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the
CC cytoplasm by interacting with their hydrophobic membrane-spanning
CC domains, and targets them to the peroxisome membrane by binding to the
CC integral membrane protein PEX3. Excludes CDKN2A from the nucleus and
CC prevents its interaction with MDM2, which results in active degradation
CC of TP53 (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with a broad range of peroxisomal membrane proteins,
CC including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16,
CC PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and
CC ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side
CC {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction membrane-
CC associated to the outer surface of peroxisomes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxin-19 family. {ECO:0000305}.
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DR EMBL; BC102949; AAI02950.1; -; mRNA.
DR RefSeq; NP_001029712.1; NM_001034540.2.
DR AlphaFoldDB; Q3SZD1; -.
DR SMR; Q3SZD1; -.
DR STRING; 9913.ENSBTAP00000009921; -.
DR PaxDb; Q3SZD1; -.
DR PeptideAtlas; Q3SZD1; -.
DR PRIDE; Q3SZD1; -.
DR Ensembl; ENSBTAT00000009921; ENSBTAP00000009921; ENSBTAG00000007537.
DR GeneID; 521522; -.
DR KEGG; bta:521522; -.
DR CTD; 5824; -.
DR VEuPathDB; HostDB:ENSBTAG00000007537; -.
DR VGNC; VGNC:32758; PEX19.
DR eggNOG; KOG3133; Eukaryota.
DR GeneTree; ENSGT00390000010993; -.
DR HOGENOM; CLU_043063_3_0_1; -.
DR InParanoid; Q3SZD1; -.
DR OMA; NPQCPTM; -.
DR OrthoDB; 1282367at2759; -.
DR TreeFam; TF315082; -.
DR Reactome; R-BTA-9603798; Class I peroxisomal membrane protein import.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000007537; Expressed in gluteus medius and 103 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016021; C:integral component of membrane; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005778; C:peroxisomal membrane; ISS:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0036105; F:peroxisome membrane class-1 targeting sequence binding; IEA:Ensembl.
DR GO; GO:0033328; F:peroxisome membrane targeting sequence binding; IBA:GO_Central.
DR GO; GO:0140597; F:protein carrier chaperone; IEA:Ensembl.
DR GO; GO:0047485; F:protein N-terminus binding; IEA:Ensembl.
DR GO; GO:0061077; P:chaperone-mediated protein folding; IEA:Ensembl.
DR GO; GO:1900131; P:negative regulation of lipid binding; IEA:Ensembl.
DR GO; GO:0016559; P:peroxisome fission; IEA:Ensembl.
DR GO; GO:0016557; P:peroxisome membrane biogenesis; ISS:UniProtKB.
DR GO; GO:0007031; P:peroxisome organization; ISS:UniProtKB.
DR GO; GO:0045046; P:protein import into peroxisome membrane; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0006625; P:protein targeting to peroxisome; ISS:UniProtKB.
DR Gene3D; 1.20.120.900; -; 1.
DR InterPro; IPR006708; Pex19.
DR InterPro; IPR038322; Pex19_C_sf.
DR PANTHER; PTHR12774; PTHR12774; 1.
DR Pfam; PF04614; Pex19; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Lipoprotein; Membrane; Methylation; Peroxisome;
KW Peroxisome biogenesis; Phosphoprotein; Prenylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P40855"
FT CHAIN 2..296
FT /note="Peroxisomal biogenesis factor 19"
FT /id="PRO_0000253623"
FT PROPEP 297..299
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000396699"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2..91
FT /note="Necessary for PEX19 function on peroxisome
FT biogenesis"
FT REGION 2..56
FT /note="Docking to the peroxisome membrane and binding to
FT PEX3"
FT COMPBIAS 9..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P40855"
FT MOD_RES 35
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P40855"
FT MOD_RES 54
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P40855"
FT MOD_RES 66
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9QYU1"
FT MOD_RES 236
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8VCI5"
FT MOD_RES 296
FT /note="Cysteine methyl ester"
FT /evidence="ECO:0000250"
FT LIPID 296
FT /note="S-farnesyl cysteine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 299 AA; 32667 MW; CCFADD95F62AB945 CRC64;
MAAAEGDGGV RAEADRELEE LLESALDDFD KAKPSPAPPP TTTAPDASGP QKRSPGDTAK
DALFASQEKF FQELFDSELA SQATAEFEKA MKELAEEEPH LVEQFQKLSE AAGRVGSDAT
SQQEFTSCLK ETLSGLAKNA TDLQNSGMSE EELTKAMEGL GMDEGDGEGT ILPIMQSIMQ
NLLSRDVLYP SLKEITEKYP EWLRAHRDSL PPEQFEKYQE QHSVMGKICE QFEAETPTDS
EATQKARFEV VLDLMQQLQD LGHPPKELAG EMPPGLNFDL DALNLSGPPG ANGEQCLIM
