ID   PEX1_PICPA              Reviewed;        1157 AA.
AC   P46463;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Peroxisome biosynthesis protein PAS1;
DE   AltName: Full=Peroxin-1;
GN   Name=PEX1; Synonyms=PAS1;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=21-1;
RX   PubMed=7962088; DOI=10.1083/jcb.127.5.1259;
RA   Heyman J.A., Monosov E., Subramani S.;
RT   "Role of the PAS1 gene of Pichia pastoris in peroxisome biogenesis.";
RL   J. Cell Biol. 127:1259-1273(1994).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis. May play a direct or
CC       indirect role in delivering membrane material to developing
CC       peroxisomes. It may also be involved in intracellular membrane
CC       movement.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the AAA ATPase family. {ECO:0000305}.
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DR   EMBL; Z36987; CAA85450.1; -; Genomic_DNA.
DR   PIR; A55152; A55152.
DR   AlphaFoldDB; P46463; -.
DR   SMR; P46463; -.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0006625; P:protein targeting to peroxisome; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR041569; AAA_lid_3.
DR   InterPro; IPR009010; Asp_de-COase-like_dom_sf.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR029067; CDC48_domain_2-like_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015342; PEX-N_psi_beta-barrel.
DR   InterPro; IPR025653; Pex1.
DR   PANTHER; PTHR23077:SF12; PTHR23077:SF12; 1.
DR   Pfam; PF00004; AAA; 2.
DR   Pfam; PF17862; AAA_lid_3; 1.
DR   Pfam; PF09262; PEX-1N; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF50692; SSF50692; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF54585; SSF54585; 1.
DR   PROSITE; PS00674; AAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Nucleotide-binding; Peroxisome biogenesis; Repeat.
FT   CHAIN           1..1157
FT                   /note="Peroxisome biosynthesis protein PAS1"
FT                   /id="PRO_0000084605"
FT   REGION          187..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1135..1157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         523..530
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         840..847
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1157 AA;  126985 MW;  B26F46F55A92DA3C CRC64;
     MNSIDAVVRY SPLRNNLCNL PSAITTMLFS ADFNIQQIIV ELSWVPHQRA AQRRIAYCGW
     AGGITKTSSS NPVIEIDRSL ASAIDLQENV NVTVNVHIDA VKAITVELEP VTSNDWEIVE
     THAQVLETYL LNQTRCVYPN QVLVVYPTPQ TTARLLVKKI EPEVSTFAQL FNDTEVQIAP
     KVQKRPSISS VRSDSSGHRI RRVRSSTSTA TGRRSVTNNG EVLPSMLRRS ITLPNNTYAH
     VNDSKSGGYK VYCNLNELIP ALQNAHFVSV SVLVGPGTPD RTGLTSSKIK QLNDSIDQAA
     QTQTNAAGSS HPPESSYTET GKVIAELVHD SKSPKGNVGL SELLACSLGI ENTVGNLISL
     EQARKPLIKK PTVLVLHKYT TVSPASLDRV TIKHATEEQK RVQNKKERDT LLTQLMQLLS
     PLLDSCTFTN CVKLPKIGTL LPNGGLLQFK RIKSGWTTPL GKDNVSLEIG EEILRPESFS
     PSYDLLPDRK THVRTQSDQY PTAQENLIES LSKIASGGSL LFGTSGSGKS LVISQVAQIV
     TNKGHFVKLL NCDKIMSESY NNLRGIFEDI FSEVSWKAPS LLILEDLDSL IPAEQEHSDS
     SQSRQLSEYF ISKLSAQTIN RDITILASSK SKESLNSLIF TTHLIEHDFQ LRAPDKEARK
     QILQSYLDTL NVFCSEGELL NNIAVETEGY LPKDLKVLCD RAYHDLISRD ILADSDSELD
     IEESSTPILN GSVGDIANKQ SEIENGISGL ELTNNSSSTI AVDKHGATIQ KDNFDSALSG
     YIPQSLRGVK LQKSDVRWDD IGGLRDAKSI LLETLEWPTK YAPIFSSCPL RLRSGILLYG
     YPGCGKTLLA SAVAAQCGLN FISIKGPEIL NKYIGPSEQS VRELFERAQA AKPCILFFDE
     FDSIAPKRGH DSTGVTDRVV NQMLTQMDGA EGLDGVYVLA ATSRPDLIDS ALLRPGRLDK
     SVICDMPDFD DRLDILQSVT RNMNVSKSVN LSSVAGECSG FSGADLQALA YNAYLKAVHE
     KLTKDESMAM AGEMDDNDDK KRMVECFQFS GNTEKKSLIE LKPSDRATVI KKLEHLYQGN
     GNHAEGETKS KLATTAANSV IITSKDFEDS LSETKQSISQ SEKRKLEAIY QQFISGRDGN
     MPDGTASNEI GARSTLM