ID   PEX21_ASHGO             Reviewed;         307 AA.
AC   Q75AS1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Peroxisomal membrane protein PEX21;
DE   AltName: Full=Peroxin-21;
GN   Name=PEX21; OrderedLocusNames=ADL151W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in peroxisome biogenesis and the import of
CC       peroxisomal matrix proteins. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxin-21 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51769.1; -; Genomic_DNA.
DR   RefSeq; NP_983945.1; NM_209298.1.
DR   AlphaFoldDB; Q75AS1; -.
DR   STRING; 33169.AAS51769; -.
DR   EnsemblFungi; AAS51769; AAS51769; AGOS_ADL151W.
DR   GeneID; 4620087; -.
DR   KEGG; ago:AGOS_ADL151W; -.
DR   eggNOG; ENOG502S8JP; Eukaryota.
DR   HOGENOM; CLU_078821_0_0_1; -.
DR   InParanoid; Q75AS1; -.
DR   OMA; CQGSAMQ; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Cytoplasm; Membrane; Peroxisome; Reference proteome.
FT   CHAIN           1..307
FT                   /note="Peroxisomal membrane protein PEX21"
FT                   /id="PRO_0000301807"
FT   REGION          23..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        33..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  32999 MW;  A5F4542854D23D60 CRC64;
     MSLCQGSAMQ KLIAKTEGPM AGVGRVGGFN RPSGGLGQSS AEQQLQARAG ERASQNRFMA
     VLEPQRELGG RMARGDGLQA DWVRQFSSMQ VEDPLAFSAE YQRAYAGYEQ RQAARPAARV
     LGYGGSMFMP TMPQQQLQQQ VAPQQTAQAA LQEAELERYL EREFDVLEGE LAPPEVPEAL
     SAPLLDHEQL GFQESAKAIY ATLSAPIHKD KFGASKFMGL MRQVSTGDVT LSKSESGYTG
     LHMTAGGEAV GAEYRAVTDE VVQVPEVAAA LPLAGEERSL ASQMEDLLNK VDIAGLSSNE
     AAMRILS