ID   PEX22_PICPA             Reviewed;         187 AA.
AC   Q9UW82;
DT   25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=Peroxisome assembly protein 22;
DE   AltName: Full=Peroxin-22;
GN   Name=PEX22;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10402463; DOI=10.1083/jcb.146.1.99;
RA   Koller A., Snyder W.B., Faber K.N., Wenzel T.J., Rangell L., Keller G.A.,
RA   Subramani S.;
RT   "Pex22p of Pichia pastoris, essential for peroxisomal matrix protein
RT   import, anchors the ubiquitin-conjugating enzyme, Pex4p, on the peroxisomal
RT   membrane.";
RL   J. Cell Biol. 146:99-112(1999).
CC   -!- FUNCTION: Involved in peroxisome biogenesis.
CC   -!- SUBUNIT: Interacts with PEX4.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the peroxin-22 family. {ECO:0000305}.
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DR   EMBL; AF133103; AAD45664.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9UW82; -.
DR   SMR; Q9UW82; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.11730; -; 1.
DR   InterPro; IPR024359; Peroxin-22.
DR   InterPro; IPR038613; Peroxin-22_C_sf.
DR   Pfam; PF12827; Peroxin-22; 1.
PE   3: Inferred from homology;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..187
FT                   /note="Peroxisome assembly protein 22"
FT                   /id="PRO_0000058338"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   187 AA;  20986 MW;  5A664EBF18ED91C4 CRC64;
     MKSTKRNTFF GLAALGALGL GYSVYKSFIT SDKPSSLINL GINQERKSYT RQKVAIIVSE
     SILAIQLPIQ EILKNTKDVV FVLAPTIAKD EFLRENEVDS GLSFKVIETG TAIGCFHVLK
     HIKATYNIFN LHDFLPSSTK TSSDNEQLTF DLEEYVNLHL NNFLQNVVEL PSDSTSIQET
     VNQYIYN