ID   PEX26_MACFA             Reviewed;         305 AA.
AC   Q9BE65; Q9N0D4;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Peroxisome assembly protein 26;
DE   AltName: Full=Peroxin-26;
GN   Name=PEX26; ORFNames=QccE-11782, QflA-13707;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex, and Frontal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably required for protein import into peroxisomes.
CC       Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form
CC       heteromeric AAA ATPase complexes required for the import of proteins
CC       into peroxisomes. Involved in the import of catalase and proteins
CC       containing a PTS2 target sequence, but not in import of proteins with a
CC       PTS1 target sequence (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts directly with PEX6 via its cytoplasmic domain.
CC       Interacts indirectly with PEX1, via its interaction with PEX6 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC       type II membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxin-26 family. {ECO:0000305}.
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DR   EMBL; AB045996; BAB01578.1; -; mRNA.
DR   EMBL; AB056805; BAB39329.1; -; mRNA.
DR   RefSeq; NP_001271556.1; NM_001284627.1.
DR   AlphaFoldDB; Q9BE65; -.
DR   SMR; Q9BE65; -.
DR   STRING; 9541.XP_005568073.1; -.
DR   GeneID; 102134428; -.
DR   CTD; 55670; -.
DR   eggNOG; ENOG502RXMN; Eukaryota.
DR   OrthoDB; 1053354at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
DR   GO; GO:0044877; F:protein-containing complex binding; ISS:UniProtKB.
DR   GO; GO:0016558; P:protein import into peroxisome matrix; ISS:UniProtKB.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; IEA:InterPro.
DR   InterPro; IPR010797; Pex26.
DR   PANTHER; PTHR16262; PTHR16262; 1.
DR   Pfam; PF07163; Pex26; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Protein transport; Reference proteome; Signal-anchor;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..305
FT                   /note="Peroxisome assembly protein 26"
FT                   /id="PRO_0000058341"
FT   TOPO_DOM        1..246
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        268..305
FT                   /note="Peroxisomal matrix"
FT                   /evidence="ECO:0000255"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        29
FT                   /note="P -> L (in Ref. 1; BAB01578)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        82
FT                   /note="K -> R (in Ref. 1; BAB01578)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        102
FT                   /note="V -> A (in Ref. 1; BAB01578)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        135
FT                   /note="R -> K (in Ref. 1; BAB01578)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="E -> K (in Ref. 1; BAB01578)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279
FT                   /note="S -> F (in Ref. 1; BAB01578)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   305 AA;  33932 MW;  3EDB8F527BC9C869 CRC64;
     MKSDCSTSAA PFRGLGGPLR SSEPVRAAPA RSPAVDLLEE AADLLVVHLD FRAALETCER
     AWQSLANHAL PEEPAGTSLE VKCSLCVVGI QALAEMDRWQ EVLSWVLQYY QVPEKLPPKV
     LELCILLYSK MQEPRAVLDV VGAWLQDPAN QDLPEYGALA EFHVQRVLLP LGCLSEAEEL
     VVGSAAFGEE RRLDVLQAIH TARQQQQQEH SGSEEAQKPN EEGSVSHKFL SLPMLVRQLW
     DSAVSHFFSL PFKKSLLAAL ILCLLVVRFD PASPSSLPSL YKLAQLFRWI RKAASSRLYQ
     LRIRD