PEX26_MOUSE
ID PEX26_MOUSE Reviewed; 305 AA.
AC Q8BGI5; Q3UGH5; Q9D661;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Peroxisome assembly protein 26;
DE AltName: Full=Peroxin-26;
GN Name=Pex26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J;
RC TISSUE=Brain cortex, Cerebellum, Oviduct, Skin, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Probably required for protein import into peroxisomes.
CC Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form
CC heteromeric AAA ATPase complexes required for the import of proteins
CC into peroxisomes. Involved in the import of catalase and proteins
CC containing a PTS2 target sequence, but not in import of proteins with a
CC PTS1 target sequence (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts directly with PEX6 via its cytoplasmic domain.
CC Interacts indirectly with PEX1, via its interaction with PEX6 (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC type II membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BGI5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BGI5-2; Sequence=VSP_010444;
CC -!- SIMILARITY: Belongs to the peroxin-26 family. {ECO:0000305}.
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DR EMBL; AK014598; BAB29453.1; -; mRNA.
DR EMBL; AK040411; BAC30589.1; -; mRNA.
DR EMBL; AK042663; BAC31324.1; -; mRNA.
DR EMBL; AK044186; BAC31808.1; -; mRNA.
DR EMBL; AK087637; BAC39952.1; -; mRNA.
DR EMBL; AK147925; BAE28233.1; -; mRNA.
DR EMBL; BC019144; AAH19144.1; -; mRNA.
DR EMBL; BC058694; AAH58694.1; -; mRNA.
DR CCDS; CCDS20488.1; -. [Q8BGI5-1]
DR CCDS; CCDS80603.1; -. [Q8BGI5-2]
DR RefSeq; NP_001291702.1; NM_001304773.1. [Q8BGI5-2]
DR RefSeq; NP_001291703.1; NM_001304774.1.
DR RefSeq; NP_083006.1; NM_028730.6. [Q8BGI5-1]
DR AlphaFoldDB; Q8BGI5; -.
DR SMR; Q8BGI5; -.
DR STRING; 10090.ENSMUSP00000085921; -.
DR iPTMnet; Q8BGI5; -.
DR PhosphoSitePlus; Q8BGI5; -.
DR EPD; Q8BGI5; -.
DR MaxQB; Q8BGI5; -.
DR PaxDb; Q8BGI5; -.
DR PRIDE; Q8BGI5; -.
DR ProteomicsDB; 289471; -. [Q8BGI5-1]
DR ProteomicsDB; 289472; -. [Q8BGI5-2]
DR Ensembl; ENSMUST00000088561; ENSMUSP00000085921; ENSMUSG00000067825. [Q8BGI5-1]
DR Ensembl; ENSMUST00000120066; ENSMUSP00000113233; ENSMUSG00000067825. [Q8BGI5-2]
DR Ensembl; ENSMUST00000125633; ENSMUSP00000117444; ENSMUSG00000067825. [Q8BGI5-1]
DR GeneID; 74043; -.
DR KEGG; mmu:74043; -.
DR UCSC; uc009dod.2; mouse. [Q8BGI5-1]
DR UCSC; uc009doe.2; mouse. [Q8BGI5-2]
DR CTD; 55670; -.
DR MGI; MGI:1921293; Pex26.
DR VEuPathDB; HostDB:ENSMUSG00000067825; -.
DR eggNOG; ENOG502RXMN; Eukaryota.
DR GeneTree; ENSGT00510000049725; -.
DR InParanoid; Q8BGI5; -.
DR OMA; KCSLCIV; -.
DR OrthoDB; 1053354at2759; -.
DR PhylomeDB; Q8BGI5; -.
DR TreeFam; TF332318; -.
DR Reactome; R-MMU-9033241; Peroxisomal protein import.
DR Reactome; R-MMU-9603798; Class I peroxisomal membrane protein import.
DR BioGRID-ORCS; 74043; 3 hits in 57 CRISPR screens.
DR ChiTaRS; Pex26; mouse.
DR PRO; PR:Q8BGI5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BGI5; protein.
DR Bgee; ENSMUSG00000067825; Expressed in secondary oocyte and 244 other tissues.
DR ExpressionAtlas; Q8BGI5; baseline and differential.
DR Genevisible; Q8BGI5; MM.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0051117; F:ATPase binding; ISO:MGI.
DR GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0016558; P:protein import into peroxisome matrix; ISO:MGI.
DR GO; GO:0045046; P:protein import into peroxisome membrane; IEA:InterPro.
DR InterPro; IPR010797; Pex26.
DR PANTHER; PTHR16262; PTHR16262; 1.
DR Pfam; PF07163; Pex26; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Peroxisome; Protein transport;
KW Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..305
FT /note="Peroxisome assembly protein 26"
FT /id="PRO_0000058342"
FT TOPO_DOM 1..246
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 268..305
FT /note="Peroxisomal matrix"
FT /evidence="ECO:0000255"
FT VAR_SEQ 272
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_010444"
SQ SEQUENCE 305 AA; 34016 MW; 501128B88CE4DB36 CRC64;
MKSDASTSAA PLKGLVGPLR SSEPALALPA VSPAVHLLEE ASDLLVVHLD FHAALETCER
AWQSLAEEPV SGTIVEVKCS LCVVGIQALA EMDRWREALS WVLRYYQVPE KLPPKVLELC
ILLYSKMKEP GAVLDVASAW LQDPDNQGLP DYGSLARLHV FRLLLPSGRL SEAEELAVRS
AAFSEEQRVE ALQAIHLARQ QHTQEHTQEH SDSQEPQKLR QEGSFSQKLL SLLMLLRRLW
GSVVSHLLSQ PFRKGLLAAL ILCLLILRFD PAAPSSLPFL YQLTQLFRRI QKATLSRLYP
LALRD
