PEX27_YEAST
ID PEX27_YEAST Reviewed; 376 AA.
AC Q08580; D6W2Q2;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Peroxisomal membrane protein PEX27;
DE AltName: Full=Peroxin-27;
GN Name=PEX27; OrderedLocusNames=YOR193W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP FUNCTION, SUBUNIT, INTERACTION WITH PEX25, AND SUBCELLULAR LOCATION.
RX PubMed=14517321; DOI=10.1091/mbc.e03-03-0150;
RA Tam Y.Y.C., Torres-Guzman J.C., Vizeacoumar F.J., Smith J.J., Marelli M.,
RA Aitchison J.D., Rachubinski R.A.;
RT "Pex11-related proteins in peroxisome dynamics: a role for the novel
RT peroxin Pex27p in controlling peroxisome size and number in Saccharomyces
RT cerevisiae.";
RL Mol. Biol. Cell 14:4089-4102(2003).
RN [5]
RP FUNCTION, SUBUNIT, INTERACTION WITH PEX25, AND SUBCELLULAR LOCATION.
RX PubMed=14517338; DOI=10.1091/mbc.e03-03-0153;
RA Rottensteiner H., Stein K., Sonnenhol E., Erdmann R.;
RT "Conserved function of pex11p and the novel pex25p and pex27p in peroxisome
RT biogenesis.";
RL Mol. Biol. Cell 14:4316-4328(2003).
RN [6]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [7]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [8]
RP FUNCTION, AND INTERACTION WITH PEX34.
RX PubMed=21441307; DOI=10.1091/mbc.e11-01-0084;
RA Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.;
RT "The peroxin Pex34p functions with the Pex11 family of peroxisomal
RT divisional proteins to regulate the peroxisome population in yeast.";
RL Mol. Biol. Cell 22:1727-1738(2011).
CC -!- FUNCTION: Required for regulation of peroxisome size and number. Also
CC promotes peroxisome division and biogenesis.
CC {ECO:0000269|PubMed:14517321, ECO:0000269|PubMed:14517338,
CC ECO:0000269|PubMed:21441307}.
CC -!- SUBUNIT: Homooligomer. Interacts with PEX25 and PEX34.
CC {ECO:0000269|PubMed:14517321, ECO:0000269|PubMed:14517338,
CC ECO:0000269|PubMed:21441307}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:14517321,
CC ECO:0000269|PubMed:14517338, ECO:0000269|PubMed:14562095}; Peripheral
CC membrane protein {ECO:0000269|PubMed:14517321,
CC ECO:0000269|PubMed:14517338, ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 382 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z75101; CAA99406.1; -; Genomic_DNA.
DR EMBL; AY723869; AAU09786.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10968.1; -; Genomic_DNA.
DR PIR; S67085; S67085.
DR RefSeq; NP_014836.3; NM_001183612.3.
DR AlphaFoldDB; Q08580; -.
DR BioGRID; 34591; 72.
DR IntAct; Q08580; 3.
DR MINT; Q08580; -.
DR STRING; 4932.YOR193W; -.
DR TCDB; 1.A.101.7.3; the peroxisomal pore-forming pex11 (pex11) family.
DR TCDB; 3.A.20.1.5; the peroxisomal protein importer (ppi) family.
DR iPTMnet; Q08580; -.
DR MaxQB; Q08580; -.
DR PaxDb; Q08580; -.
DR PRIDE; Q08580; -.
DR EnsemblFungi; YOR193W_mRNA; YOR193W; YOR193W.
DR GeneID; 854368; -.
DR KEGG; sce:YOR193W; -.
DR SGD; S000005719; PEX27.
DR VEuPathDB; FungiDB:YOR193W; -.
DR HOGENOM; CLU_736106_0_0_1; -.
DR OMA; FFDIIEA; -.
DR BioCyc; YEAST:G3O-33702-MON; -.
DR PRO; PR:Q08580; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08580; protein.
DR GO; GO:0005778; C:peroxisomal membrane; IDA:SGD.
DR GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR GO; GO:0016559; P:peroxisome fission; IDA:UniProtKB.
DR GO; GO:0007031; P:peroxisome organization; IMP:SGD.
DR GO; GO:0044375; P:regulation of peroxisome size; IDA:UniProtKB.
PE 1: Evidence at protein level;
KW Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome.
FT CHAIN 1..376
FT /note="Peroxisomal membrane protein PEX27"
FT /id="PRO_0000270569"
SQ SEQUENCE 376 AA; 44131 MW; 976FDBCA43AB4F80 CRC64;
MTSDPVNTNI SSPTLTDRNA DESWELLKRE FNTLFSNLKT DSKEEGNFTD NKGVIAKKPI
VLQDNDDSDF TQNQGKVATA TSTTSDRSFK RTLGSIEMKK RYVKKNCQAK FVFNTLEGKE
VCSKILQHTL GLLSLLLLTR KIRLLNFSSK LRLVIQQLSL FRYYLRFGNF AINLYKIIKR
FRWLREMKKL HYKDQSILFY FKNFRFFDII EAFYNLTDEL ILFHKLQSMF GKKNTSHANT
NRLMTFVKEQ HYILWEVLNI LAINKNIEQW RQLIRDEIYL SIYNTSGNAI KEYELKYKLP
TNDKVNLELR KNNITLDFYK IILNLLSNLI NIKGKRDKYN SELAYEIISV GSGVTELLKL
WNRAKVTSAN EHTSAV
