PEX28_YEAST
ID PEX28_YEAST Reviewed; 579 AA.
AC P38848; D3DL99;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1995, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Peroxisomal membrane protein PEX28;
DE AltName: Full=Peroxin-28;
GN Name=PEX28; OrderedLocusNames=YHR150W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091229; DOI=10.1126/science.8091229;
RA Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA Waterston R., Wilson R., Vaudin M.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT VIII.";
RL Science 265:2077-2082(1994).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12707309; DOI=10.1083/jcb.200210130;
RA Vizeacoumar F.J., Torres-Guzman J.C., Tam Y.Y.C., Aitchison J.D.,
RA Rachubinski R.A.;
RT "YHR150w and YDR479c encode peroxisomal integral membrane proteins involved
RT in the regulation of peroxisome number, size, and distribution in
RT Saccharomyces cerevisiae.";
RL J. Cell Biol. 161:321-332(2003).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Involved in the regulation of peroxisome number, size and
CC distribution. {ECO:0000269|PubMed:12707309}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000269|PubMed:12707309}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12707309}.
CC -!- SIMILARITY: Belongs to the peroxin-2832 family. Peroxin-28 subfamily.
CC {ECO:0000305}.
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DR EMBL; U10397; AAB68980.1; -; Genomic_DNA.
DR EMBL; BK006934; DAA06843.1; -; Genomic_DNA.
DR PIR; S46757; S46757.
DR RefSeq; NP_012020.1; NM_001179281.1.
DR AlphaFoldDB; P38848; -.
DR BioGRID; 36584; 62.
DR STRING; 4932.YHR150W; -.
DR TCDB; 3.A.20.1.5; the peroxisomal protein importer (ppi) family.
DR iPTMnet; P38848; -.
DR MaxQB; P38848; -.
DR PaxDb; P38848; -.
DR PRIDE; P38848; -.
DR EnsemblFungi; YHR150W_mRNA; YHR150W; YHR150W.
DR GeneID; 856555; -.
DR KEGG; sce:YHR150W; -.
DR SGD; S000001193; PEX28.
DR VEuPathDB; FungiDB:YHR150W; -.
DR eggNOG; ENOG502QUW8; Eukaryota.
DR HOGENOM; CLU_034954_0_0_1; -.
DR InParanoid; P38848; -.
DR OMA; WRLIFIQ; -.
DR BioCyc; YEAST:G3O-31185-MON; -.
DR PRO; PR:P38848; -.
DR Proteomes; UP000002311; Chromosome VIII.
DR RNAct; P38848; protein.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; IDA:SGD.
DR GO; GO:0007031; P:peroxisome organization; IDA:SGD.
DR InterPro; IPR010482; Peroxin.
DR Pfam; PF06398; Pex24p; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Peroxisome; Peroxisome biogenesis;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..579
FT /note="Peroxisomal membrane protein PEX28"
FT /id="PRO_0000202925"
FT TOPO_DOM 1..243
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..392
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 393..413
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 414..579
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 40..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 361
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 579 AA; 66148 MW; 2A6A73999C54C19E CRC64;
MSETSSSRRS ASKDAVKSYF AGKYNKVLDS ILEAEAAISK SPTVAEDLSG SSSSGNSEMS
HPSLTASSAT SQGISKKELL QQIAGSLFST SIERLKTAHS SEVSSTPEYS VNDSYGEQEC
RECDGVFKCS AHFEGAPEYY DDETESGPAL EPMTSNSEKD PFIDVFLDKL ISRLVPEKLP
EREHFSSKTT IEHDLDTGRV PVFSATTLGS NFKKLSKKMG SIFELQDSIV RLLTWRNPTG
TVTSLILFTL ICFNPMYLVI LPIFRFVYGI VVPGYVRKHP LQRSIYPLKR NHGSSLLYDV
CYEGKNEYSY GQQFFSKSFM DTLESRNQEI DEISELDKRT ENTGELKQGM KVLINLRDMQ
NMTSGTLHVI EAINSFLRKS SSFQNEECST KRFFTGFLLI VFLKILSPFV NWSYVCSIFA
WCLLIYMHPR AHPKIISFFK TGTMGKEYKN LKKREHQALN MIFDEQPETK FIEIFEIYKK
ALLPNDWKFF RYSNRIFDPQ DPYRRAQQFP PGVDSLADVI PPTGWSFDPN FEWKIDNDVD
RWVVERGLNL PITGEFLFDP MFKRRRLIHR VIKNATPVA
