PEX29_YEAST
ID PEX29_YEAST Reviewed; 554 AA.
AC Q03370; D6VTA2;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Peroxisomal membrane protein PEX29;
DE AltName: Full=Peroxin-29;
GN Name=PEX29; OrderedLocusNames=YDR479C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=12707309; DOI=10.1083/jcb.200210130;
RA Vizeacoumar F.J., Torres-Guzman J.C., Tam Y.Y.C., Aitchison J.D.,
RA Rachubinski R.A.;
RT "YHR150w and YDR479c encode peroxisomal integral membrane proteins involved
RT in the regulation of peroxisome number, size, and distribution in
RT Saccharomyces cerevisiae.";
RL J. Cell Biol. 161:321-332(2003).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
CC -!- FUNCTION: Involved in the regulation of peroxisome number, size and
CC distribution. {ECO:0000269|PubMed:12707309}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000269|PubMed:12707309}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:12707309}.
CC -!- MISCELLANEOUS: Present with 5040 molecules/cell.
CC -!- SIMILARITY: Belongs to the PEX28-32 family. PEX29 subfamily.
CC {ECO:0000305}.
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DR EMBL; U33050; AAB64918.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12312.1; -; Genomic_DNA.
DR PIR; S69646; S69646.
DR RefSeq; NP_010767.1; NM_001180787.1.
DR AlphaFoldDB; Q03370; -.
DR BioGRID; 32531; 163.
DR DIP; DIP-5175N; -.
DR IntAct; Q03370; 42.
DR MINT; Q03370; -.
DR STRING; 4932.YDR479C; -.
DR TCDB; 3.A.20.1.5; the peroxisomal protein importer (ppi) family.
DR iPTMnet; Q03370; -.
DR MaxQB; Q03370; -.
DR PaxDb; Q03370; -.
DR PRIDE; Q03370; -.
DR EnsemblFungi; YDR479C_mRNA; YDR479C; YDR479C.
DR GeneID; 852090; -.
DR KEGG; sce:YDR479C; -.
DR SGD; S000002887; PEX29.
DR VEuPathDB; FungiDB:YDR479C; -.
DR eggNOG; ENOG502QQTF; Eukaryota.
DR HOGENOM; CLU_023118_1_0_1; -.
DR InParanoid; Q03370; -.
DR OMA; QNCMEDF; -.
DR BioCyc; YEAST:G3O-30005-MON; -.
DR PRO; PR:Q03370; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03370; protein.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; IDA:SGD.
DR GO; GO:0005777; C:peroxisome; IDA:SGD.
DR GO; GO:0032581; P:ER-dependent peroxisome organization; IGI:SGD.
DR GO; GO:0007031; P:peroxisome organization; IDA:SGD.
DR InterPro; IPR010482; Peroxin.
DR Pfam; PF06398; Pex24p; 1.
PE 1: Evidence at protein level;
KW Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..554
FT /note="Peroxisomal membrane protein PEX29"
FT /id="PRO_0000252269"
FT TOPO_DOM 1..145
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 167..172
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..264
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 265..285
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 286..287
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 309..554
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 11..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 63543 MW; C2EB849C36FB69EB CRC64;
MDSVTNFFWN DTYNAGTPTR STLKGKKVQN GIDGKSQAKK ESISSGSRTS DPTRGSLPSS
SGQPTSGGGF PSTSNIQKMM ADTLVEKIIK MALPPSSKTA VDTIHHRMVA GKERPKLSVQ
ITSRNFIQMN SRLGVPFMIM DELIKILNWT NPAYTVSIMF LYTLIILKPF QMLSSLPIFY
LLFCVMVPQY LYIHKPNPTS YLDNNQTPAQ GPPLRRPEVP KPVPELSQEF VLNLTDLQNH
MLLYVKFYDF TLLILQKFAF FTNEAISSFY FIVLLIIATL NFLYMDKFIK LIPMRPVLIL
LGWGFFIASH PSNREYLLTK LNSEETRLKT LTISTNLESK ILQHLKLIEA REHRLVMIFE
IQKYLPEYKE WRPVGFSDDD YSLFSSLRIY QRRIEENSVK SLEEIEPPKD WEWEANSHWV
LDLDPKEWVE DEFIQYVEID SETKWVYDLN LDGQRGSYRR RMWTNSCVRK KLDSGISSNL
GEEEVVNPLR EETYRQGVHG VTKGSMSGGL THSSDDDRAD EESINGTIPN LNNIDADASY
PSIEELTDTL NSTI
