ID   PEX2_DICDI              Reviewed;         423 AA.
AC   Q75JQ3; Q559N0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Peroxisome biogenesis factor 2;
DE   AltName: Full=Peroxin-2;
GN   Name=pex2; ORFNames=DDB_G0272234;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; AAFI02000008; EAL71269.1; -; Genomic_DNA.
DR   RefSeq; XP_645304.1; XM_640212.1.
DR   AlphaFoldDB; Q75JQ3; -.
DR   STRING; 44689.DDB0238045; -.
DR   PaxDb; Q75JQ3; -.
DR   EnsemblProtists; EAL71269; EAL71269; DDB_G0272234.
DR   GeneID; 8618470; -.
DR   KEGG; ddi:DDB_G0272234; -.
DR   dictyBase; DDB_G0272234; pex2.
DR   eggNOG; KOG2879; Eukaryota.
DR   HOGENOM; CLU_024591_3_1_1; -.
DR   InParanoid; Q75JQ3; -.
DR   OMA; SCFHGFK; -.
DR   PhylomeDB; Q75JQ3; -.
DR   PRO; PR:Q75JQ3; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IC:dictyBase.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007031; P:peroxisome organization; ISS:dictyBase.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW   Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..423
FT                   /note="Peroxisome biogenesis factor 2"
FT                   /id="PRO_0000371403"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         369..410
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          1..46
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   423 AA;  48982 MW;  9DDCF47269BA4315 CRC64;
     MVDNYNNNNI LPTNTSTTTT TNTTITPTPP LPPPPPISNI LDNNNNNNLI KNDIKNDKVA
     VSNSNVRPSS SSVSYENSDW NKVYNSEREK LHEVNKQILN IKRPSTSIVR VSQLDSARLD
     EEILDLLRSQ FMKIFTFFKP NFIHNFQPEI NLVLKSVIYK LSIFNLGTTY GNQLQNLTYR
     NEKAFDPIRG SDQLNKLTMR QKWLSGLINI GGEWLWTRIN RYLINNNWSE HPPNDIRKKF
     WNFLNFAESA YKALALLNFL TFLFNGKYVT LVNRILHMRL VYAHPTLSRN ISFEYMNRLL
     VWHGFTEFIL FIMPLINIDR IKSFLYRLLV KTSFGNSSGN NNNTASNPLQ QLQKQQLLIQ
     QQQMALAKCP ICMNDPISMP YSADCGHLFC YYCIKTSCMI DSSFTCPRCN SLISNIKRFS
     IQD