PEX2_MOUSE
ID PEX2_MOUSE Reviewed; 305 AA.
AC P55098; O35467;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 150.
DE RecName: Full=Peroxisome biogenesis factor 2;
DE AltName: Full=Peroxin-2;
DE AltName: Full=Peroxisomal membrane protein 3;
DE AltName: Full=Peroxisome assembly factor 1;
DE Short=PAF-1;
GN Name=Pex2; Synonyms=Paf1, Pmp35, Pxmp3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Swiss Webster; TISSUE=Liver;
RX PubMed=8043297; DOI=10.1006/bmmb.1994.1018;
RA Wilson G.N., Bryant D.D.;
RT "Structure and expression of mammalian peroxisome assembly factor-1 (PMP35)
RT genes.";
RL Biochem. Med. Metab. Biol. 51:140-148(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX PubMed=9382874; DOI=10.1083/jcb.139.5.1293;
RA Faust P.L., Hatten M.E.;
RT "Targeted deletion of the PEX2 peroxisome assembly gene in mice provides a
RT model for Zellweger syndrome, a human neuronal migration disorder.";
RL J. Cell Biol. 139:1293-1305(1997).
CC -!- FUNCTION: Somewhat implicated in the biogenesis of peroxisomes.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L27842; AAA21742.1; -; Genomic_DNA.
DR EMBL; AF031128; AAB91465.1; -; mRNA.
DR PIR; I52362; I52362.
DR RefSeq; NP_001156773.1; NM_001163301.2.
DR RefSeq; NP_001156774.1; NM_001163302.2.
DR RefSeq; NP_001156777.1; NM_001163305.2.
DR RefSeq; NP_001156778.1; NM_001163306.2.
DR RefSeq; NP_001254643.1; NM_001267714.1.
DR RefSeq; NP_001254644.1; NM_001267715.1.
DR RefSeq; NP_033020.2; NM_008994.4.
DR RefSeq; XP_006530121.1; XM_006530058.3.
DR RefSeq; XP_006530122.1; XM_006530059.2.
DR RefSeq; XP_011246442.1; XM_011248140.2.
DR RefSeq; XP_017174994.1; XM_017319505.1.
DR AlphaFoldDB; P55098; -.
DR BioGRID; 202524; 1.
DR IntAct; P55098; 2.
DR MINT; P55098; -.
DR STRING; 10090.ENSMUSP00000071255; -.
DR PhosphoSitePlus; P55098; -.
DR MaxQB; P55098; -.
DR PRIDE; P55098; -.
DR ProteomicsDB; 289473; -.
DR DNASU; 19302; -.
DR GeneID; 19302; -.
DR KEGG; mmu:19302; -.
DR CTD; 5828; -.
DR MGI; MGI:107486; Pex2.
DR eggNOG; KOG2879; Eukaryota.
DR InParanoid; P55098; -.
DR OrthoDB; 1494604at2759; -.
DR PhylomeDB; P55098; -.
DR BioGRID-ORCS; 19302; 10 hits in 72 CRISPR screens.
DR ChiTaRS; Pex2; mouse.
DR PRO; PR:P55098; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P55098; protein.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; ISO:MGI.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; ISO:MGI.
DR GO; GO:0016020; C:membrane; ISO:MGI.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:MGI.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006699; P:bile acid biosynthetic process; IMP:MGI.
DR GO; GO:0042632; P:cholesterol homeostasis; IMP:MGI.
DR GO; GO:0006635; P:fatty acid beta-oxidation; ISO:MGI.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:MGI.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0007399; P:nervous system development; IMP:MGI.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0007031; P:peroxisome organization; ISO:MGI.
DR GO; GO:0031648; P:protein destabilization; ISO:MGI.
DR GO; GO:0016558; P:protein import into peroxisome matrix; ISO:MGI.
DR GO; GO:0045540; P:regulation of cholesterol biosynthetic process; IMP:MGI.
DR GO; GO:0000038; P:very long-chain fatty acid metabolic process; ISO:MGI.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..305
FT /note="Peroxisome biogenesis factor 2"
FT /id="PRO_0000056370"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 244..284
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT CONFLICT 1..8
FT /note="MAAREEST -> MTGKEENM (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 85
FT /note="H -> Y (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 91..94
FT /note="PNPV -> LNLI (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 101
FT /note="N -> T (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 105
FT /note="L -> W (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 114
FT /note="R -> K (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 138
FT /note="C -> F (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 142
FT /note="V -> L (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="M -> I (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 225..227
FT /note="TLC -> IPL (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="A -> S (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
FT CONFLICT 298
FT /note="Q -> E (in Ref. 2; AAB91465)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 305 AA; 34732 MW; FAFB6C8913F959F0 CRC64;
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL
WLFLWRFTIY SKNATVGQSV LNIQHKNDSS PNPVYQPPSK NQKLLYAVCT IGGRWLEERC
YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE LMNFLIFLQK GKFATLTERL LGIHSVFCKP
QNMREVGFEY MNRELLWHGF AEFLIFLLPL INIQKLKAKL SSWCTLCTGA AGHDSTLGSS
GKECALCGEW PTMPHTIGCE HVFCYYCVKS SFLFDIYFTC PKCGTEVHSV QPLKAGIQMS
EVNAL
