ID   PEX2_PICPA              Reviewed;         461 AA.
AC   Q01964;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Peroxisomal biogenesis factor 2;
DE   AltName: Full=Peroxin-2;
DE   AltName: Full=Peroxisomal protein PER6;
GN   Name=PEX2; Synonyms=PER6;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 76273 / CBS 7435 / CECT 11407 / NRRL Y-11430;
RX   PubMed=8628321; DOI=10.1128/mcb.16.5.2527;
RA   Waterham H.R., de Vries Y., Russell K.A., Xie W., Veenhuis M., Cregg J.M.;
RT   "The Pichia pastoris PER6 gene product is a peroxisomal integral membrane
RT   protein essential for peroxisome biogenesis and has sequence similarity to
RT   the Zellweger syndrome protein PAF-1.";
RL   Mol. Cell. Biol. 16:2527-2536(1996).
CC   -!- FUNCTION: Essential for peroxisome biogenesis.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; X96945; CAA65646.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q01964; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..461
FT                   /note="Peroxisomal biogenesis factor 2"
FT                   /id="PRO_0000056372"
FT   TRANSMEM        172..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         281..323
FT                   /note="RING-type; atypical"
FT   REGION          374..408
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          440..461
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   461 AA;  52282 MW;  6B5FC3C7D2A0AF2A CRC64;
     MPNRLIPLAN PANRVLQLDA KLLDNEISDM LYRQLSGAFN SNRLPSWLGR IHSNYASELK
     LLLELLIFKV TVWNKHSSYG LTLQNLVMYD GGVHNKKFRS KQQSELRVTK KILLLSSVLL
     GYFVKKIQSY VYSFEDYDLE TDGEDLSTLE RIRLKTIKLL KSQISTLEKA HSVLSLVNFV
     TFLVSGSFPD LTTRILNIRF KPLVTTQVAF ASNPETISYE FQNRQLVWNT LTEFIVFILP
     ALSVPKFTKS LVSSITGTSP KSSQVTDEDL KVFSSLPERV CAICFQNSQN SDSGAQNDIS
     LNDTLVTNPY ETTCGHIYCY VCILSKLQIF KEEGKNLPKS DPNKYWHCLR CNEPASWCRV
     YTGDVEDALR QKAVEEVTED EDASSEDEEK RDQDSEGAKT VSQSFHHVNG SDYQTASFIE
     QAELNENEYT DGSEVEIYDA EDEYTDEEVD DDSPGFFVGA L