PEX2_RAT
ID PEX2_RAT Reviewed; 305 AA.
AC P24392; Q63733;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-1992, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Peroxisome biogenesis factor 2;
DE AltName: Full=Peroxin-2;
DE AltName: Full=Peroxisomal membrane protein 3;
DE AltName: Full=Peroxisome assembly factor 1;
DE Short=PAF-1;
GN Name=Pex2; Synonyms=Paf1, Pmp35, Pxmp3;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RX PubMed=1750930; DOI=10.1038/350077a0;
RA Tsukamoto T., Miura S., Fujiki Y.;
RT "Restoration by a 35K membrane protein of peroxisome assembly in a
RT peroxisome-deficient mammalian cell mutant.";
RL Nature 350:77-81(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=8035823; DOI=10.1128/mcb.14.8.5458-5465.1994;
RA Tsukamoto T., Shimozawa N., Fujiki Y.;
RT "Peroxisome assembly factor 1: nonsense mutation in a peroxisome-deficient
RT Chinese hamster ovary cell mutant and deletion analysis.";
RL Mol. Cell. Biol. 14:5458-5465(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pituitary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Somewhat implicated in the biogenesis of peroxisomes.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR EMBL; X57988; CAA41054.1; -; mRNA.
DR EMBL; D30616; BAA06306.1; -; mRNA.
DR EMBL; D30617; BAA06307.1; -; mRNA.
DR EMBL; BC063169; AAH63169.1; -; mRNA.
DR PIR; B53782; B53782.
DR RefSeq; NP_058930.1; NM_017234.1.
DR RefSeq; XP_006232222.1; XM_006232160.3.
DR RefSeq; XP_006232223.1; XM_006232161.2.
DR AlphaFoldDB; P24392; -.
DR STRING; 10116.ENSRNOP00000011579; -.
DR PaxDb; P24392; -.
DR Ensembl; ENSRNOT00000095560; ENSRNOP00000076831; ENSRNOG00000008748.
DR GeneID; 29534; -.
DR KEGG; rno:29534; -.
DR UCSC; RGD:61814; rat.
DR CTD; 5828; -.
DR RGD; 61814; Pex2.
DR eggNOG; KOG2879; Eukaryota.
DR GeneTree; ENSGT00390000001846; -.
DR HOGENOM; CLU_024591_3_1_1; -.
DR InParanoid; P24392; -.
DR OMA; SCFHGFK; -.
DR OrthoDB; 1494604at2759; -.
DR PhylomeDB; P24392; -.
DR TreeFam; TF105312; -.
DR PRO; PR:P24392; -.
DR Proteomes; UP000002494; Chromosome 2.
DR Bgee; ENSRNOG00000008748; Expressed in quadriceps femoris and 20 other tissues.
DR Genevisible; P24392; RN.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; ISO:RGD.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; ISO:RGD.
DR GO; GO:0016020; C:membrane; IDA:RGD.
DR GO; GO:0005778; C:peroxisomal membrane; IDA:HGNC-UCL.
DR GO; GO:0005777; C:peroxisome; IDA:HGNC-UCL.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006699; P:bile acid biosynthetic process; ISO:RGD.
DR GO; GO:0042632; P:cholesterol homeostasis; ISO:RGD.
DR GO; GO:0006635; P:fatty acid beta-oxidation; ISO:RGD.
DR GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
DR GO; GO:0048147; P:negative regulation of fibroblast proliferation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0007399; P:nervous system development; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; ISO:RGD.
DR GO; GO:0007031; P:peroxisome organization; ISO:RGD.
DR GO; GO:0031648; P:protein destabilization; ISO:RGD.
DR GO; GO:0016558; P:protein import into peroxisome matrix; ISO:RGD.
DR GO; GO:0045540; P:regulation of cholesterol biosynthetic process; ISO:RGD.
DR GO; GO:0000038; P:very long-chain fatty acid metabolic process; ISO:RGD.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR006845; Pex_N.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF04757; Pex2_Pex12; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW Membrane; Metal-binding; Peroxisome; Peroxisome biogenesis;
KW Reference proteome; Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT CHAIN 1..305
FT /note="Peroxisome biogenesis factor 2"
FT /id="PRO_0000056371"
FT TRANSMEM 140..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 195..213
FT /note="Helical"
FT /evidence="ECO:0000255"
FT ZN_FING 244..284
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT VARIANT 125
FT /note="R -> P"
SQ SEQUENCE 305 AA; 34768 MW; 249058A5A5A8E854 CRC64;
MAAREESTQS ANRVLRISQL DALELNKALE QLVWSQFTQC FHGFKPGLLA RFEPEVKAFL
WLFLWRFTIY SKNATVGQSV LNIQYKNDSS PNPVYQPPSK NQKLLYAVCT IGGRWLEERC
YDLFRNRHLA SFGKAKQCMN FVVGLLKLGE LMNFLIFLQK GKFATLTERL LGIHSVFCKP
QSMREVGFEY MNRELLWHGF AEFLVFLLPL INIQKLKAKL SSWCIPLTST AGSDSTLGSS
GKECALCGEW PTMPHTIGCE HVFCYYCVKS SFLFDMYFTC PKCGTEVHSV QPLKSGIEMS
EVNAL
