ID   PEX2_YARLI              Reviewed;         381 AA.
AC   Q99155; Q6C3B7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Peroxisomal biogenesis factor 2;
DE   AltName: Full=Peroxin-2;
DE   AltName: Full=Peroxisomal protein PAY5;
GN   Name=PEX2; Synonyms=PAY5; OrderedLocusNames=YALI0F01012g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8702763; DOI=10.1074/jbc.271.34.20307;
RA   Eitzen G.A., Titorenko V.I., Smith J.J., Veenhuis M., Szilard R.K.,
RA   Rachubinski R.A.;
RT   "The Yarrowia lipolytica gene PAY5 encodes a peroxisomal integral membrane
RT   protein homologous to the mammalian peroxisome assembly factor PAF-1.";
RL   J. Biol. Chem. 271:20300-20306(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Required for the import of several proteins into peroxisomes.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
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DR   EMBL; U43081; AAC49423.1; -; Genomic_DNA.
DR   EMBL; CR382132; CAG77647.1; -; Genomic_DNA.
DR   RefSeq; XP_504845.1; XM_504845.1.
DR   AlphaFoldDB; Q99155; -.
DR   STRING; 4952.CAG77647; -.
DR   EnsemblFungi; CAG77647; CAG77647; YALI0_F01012g.
DR   GeneID; 2908531; -.
DR   KEGG; yli:YALI0F01012g; -.
DR   VEuPathDB; FungiDB:YALI0_F01012g; -.
DR   HOGENOM; CLU_024591_0_0_1; -.
DR   InParanoid; Q99155; -.
DR   OMA; SCFHGFK; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR006845; Pex_N.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF04757; Pex2_Pex12; 1.
DR   SMART; SM00184; RING; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   3: Inferred from homology;
KW   Membrane; Metal-binding; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..381
FT                   /note="Peroxisomal biogenesis factor 2"
FT                   /id="PRO_0000056374"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         266..324
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   REGION          355..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        358..374
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        177
FT                   /note="Missing (in Ref. 1; AAC49423)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        375
FT                   /note="N -> T (in Ref. 1; AAC49423)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   381 AA;  42897 MW;  FF5ED526AEB36043 CRC64;
     MSSVLRLFKI GAPVPNVRVH QLDASLLDAE LVDLLKNQLF KGFTNFHPEF RDKYESELVL
     ALKLILFKLT VWDHAITYGG KLQNLKFIDS RHSSKLQIQP SVIQKLGYGI LVVGGGYLWS
     KIEGYLLARS EDDVATDGTS VRGASAARGA LKVANFASLL YSAATLGNFV AFLYTGRYAT
     VIMRLLRIRL VPSQRTSSRQ VSYEFQNRQL VWNAFTEFLI FILPLLQLPK LKRRIERKLQ
     SLNVTRVGNV EEASEGELAH LPQKTCAICF RDEEEQEGGG GASHYSTDVT NPYQADCGHV
     YCYVCLVTKL AQGDGDGWNC YRCAKQVQKM KPWVDVDEAA VVGAAEMHEK VDVIEHAEDN
     EQEEEEFDDD DEDSNFQLMK D