PEX34_YEAST
ID PEX34_YEAST Reviewed; 144 AA.
AC P25584; D6VQW1;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Peroxisomal membrane protein PEX34;
DE AltName: Full=Peroxin-34;
GN Name=PEX34; OrderedLocusNames=YCL056C; ORFNames=YCL433, YCL56C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1441748; DOI=10.1002/yea.320080813;
RA Defoor E., Debrabandere R., Keyers B., Voet M., Volckaert G.;
RT "Nucleotide sequence of D10B, a BamHI fragment on the small-ring chromosome
RT III of Saccharomyces cerevisiae.";
RL Yeast 8:681-687(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP SUBCELLULAR LOCATION, FUNCTION, SUBUNIT, AND INTERACTION WITH PEX11; PEX25
RP AND PEX27.
RX PubMed=21441307; DOI=10.1091/mbc.e11-01-0084;
RA Tower R.J., Fagarasanu A., Aitchison J.D., Rachubinski R.A.;
RT "The peroxin Pex34p functions with the Pex11 family of peroxisomal
RT divisional proteins to regulate the peroxisome population in yeast.";
RL Mol. Biol. Cell 22:1727-1738(2011).
CC -!- FUNCTION: In concert with the three peroxisome divisional factors,
CC PEX11, PEX25 and PEX27, controls peroxisome morphology and abundance
CC under conditions of peroxisome proliferation. Maintains mature
CC peroxisomes in actively dividing cells. {ECO:0000269|PubMed:21441307}.
CC -!- SUBUNIT: Homooligomer. Interacts with PEX11, PEX25 and PEX27.
CC {ECO:0000269|PubMed:21441307}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:14562095,
CC ECO:0000269|PubMed:21441307}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:21441307}.
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DR EMBL; X59720; CAA42389.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07430.1; -; Genomic_DNA.
DR PIR; S19386; S19386.
DR RefSeq; NP_009875.1; NM_001178700.1.
DR AlphaFoldDB; P25584; -.
DR BioGRID; 30930; 53.
DR DIP; DIP-2040N; -.
DR IntAct; P25584; 18.
DR MINT; P25584; -.
DR STRING; 4932.YCL056C; -.
DR TCDB; 3.A.20.1.5; the peroxisomal protein importer (ppi) family.
DR PaxDb; P25584; -.
DR PRIDE; P25584; -.
DR EnsemblFungi; YCL056C_mRNA; YCL056C; YCL056C.
DR GeneID; 850302; -.
DR KEGG; sce:YCL056C; -.
DR SGD; S000000561; PEX34.
DR VEuPathDB; FungiDB:YCL056C; -.
DR HOGENOM; CLU_1797567_0_0_1; -.
DR InParanoid; P25584; -.
DR BioCyc; YEAST:G3O-29308-MON; -.
DR PRO; PR:P25584; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25584; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IDA:SGD.
DR GO; GO:0007031; P:peroxisome organization; IMP:SGD.
PE 1: Evidence at protein level;
KW Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..144
FT /note="Peroxisomal membrane protein PEX34"
FT /id="PRO_0000202551"
FT TRANSMEM 18..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..73
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..131
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 144 AA; 16593 MW; 6035D449766516A6 CRC64;
MVSKKNTAEI SAKDIWENIW SGVSSLLDFF AVLENLGVVN DKLYVSGLLR KVWLCYSCIS
VIKCVWKLIK LCKVKFKIDQ RLDGEGNGLV KDKLINFKKK YNEHIRHITA ALLQDLSYLM
VLIYPGTRLF KRLSNIITLC RIIV
