PEX3_ASHGO
ID PEX3_ASHGO Reviewed; 446 AA.
AC Q759H4;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Peroxisomal biogenesis factor 3;
DE AltName: Full=Peroxin-3;
GN Name=PEX3; OrderedLocusNames=ADR296C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in peroxisome biosynthesis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR EMBL; AE016817; AAS52217.1; -; Genomic_DNA.
DR RefSeq; NP_984393.1; NM_209746.1.
DR AlphaFoldDB; Q759H4; -.
DR SMR; Q759H4; -.
DR STRING; 33169.AAS52217; -.
DR EnsemblFungi; AAS52217; AAS52217; AGOS_ADR296C.
DR GeneID; 4620555; -.
DR KEGG; ago:AGOS_ADR296C; -.
DR eggNOG; KOG4444; Eukaryota.
DR HOGENOM; CLU_017002_0_0_1; -.
DR InParanoid; Q759H4; -.
DR OMA; KQRFIQT; -.
DR Proteomes; UP000000591; Chromosome IV.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR GO; GO:0032581; P:ER-dependent peroxisome organization; IEA:EnsemblFungi.
DR GO; GO:0045033; P:peroxisome inheritance; IEA:EnsemblFungi.
DR GO; GO:0045046; P:protein import into peroxisome membrane; IBA:GO_Central.
DR InterPro; IPR006966; Peroxin-3.
DR PANTHER; PTHR28080; PTHR28080; 1.
DR Pfam; PF04882; Peroxin-3; 2.
PE 3: Inferred from homology;
KW Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..446
FT /note="Peroxisomal biogenesis factor 3"
FT /id="PRO_0000208741"
FT TOPO_DOM 1..12
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..446
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 101..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 49700 MW; DDED917FD2D89C93 CRC64;
MARTGLQRHR GKLLGTGAVL GGLVVAGVVA AVAAKRWVRR QQQRLSEQHY VREQIKRRFT
QTQQDALYTM YELVPVLALV LGKELDVEEL VETLKGKKLK RAGEDDEQGS GGHASAGEGS
VSSTVARSKA ELWQELKMRS AVKLLAVVYT TCMLLLLTRL QLNILARREY LETAIRVAKG
EEATRRDAAG WLGAVWEYGA AALGALGPRP AVTAVEPVDQ HEETRYVNEQ AFLSLSWWLL
NRGWLQFKPL IERQVEQQFG TLSPRDTLSM EQFSARLSNT IHAVNRELFD SDSRALLLRA
LLPDATEELH VLQQTLDEGS LRVIERDDSM LRELLQETCR CAESTASLIV LESLVNESFQ
FVMQQLETKV TKKLRKPATD APEADGAADA PSQKFQVALY SVALKDCCQE MLKNGLVSMN
NEYLQDLDAV PELDDLSASV YSNFGV
