ID   PEX3_BOVIN              Reviewed;         373 AA.
AC   A6H7C2;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=Peroxisomal biogenesis factor 3;
DE   AltName: Full=Peroxin-3;
DE   AltName: Full=Peroxisomal assembly protein PEX3;
GN   Name=PEX3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peroxisome biosynthesis and integrity. Assembles
CC       membrane vesicles before the matrix proteins are translocated. As a
CC       docking factor for PEX19, is necessary for the import of peroxisomal
CC       membrane proteins in the peroxisomes (By similarity).
CC       {ECO:0000250|UniProtKB:P56589}.
CC   -!- SUBUNIT: Interacts with PEX19. {ECO:0000250|UniProtKB:P56589}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:P56589}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P56589}.
CC   -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR   EMBL; BC146192; AAI46193.1; -; mRNA.
DR   RefSeq; NP_001092457.1; NM_001098987.1.
DR   AlphaFoldDB; A6H7C2; -.
DR   SMR; A6H7C2; -.
DR   STRING; 9913.ENSBTAP00000002294; -.
DR   PaxDb; A6H7C2; -.
DR   PRIDE; A6H7C2; -.
DR   GeneID; 515730; -.
DR   KEGG; bta:515730; -.
DR   CTD; 8504; -.
DR   eggNOG; KOG4444; Eukaryota.
DR   InParanoid; A6H7C2; -.
DR   OrthoDB; 891261at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; IBA:GO_Central.
DR   InterPro; IPR006966; Peroxin-3.
DR   PANTHER; PTHR28080; PTHR28080; 1.
DR   Pfam; PF04882; Peroxin-3; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..373
FT                   /note="Peroxisomal biogenesis factor 3"
FT                   /id="PRO_0000356189"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..116
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..373
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..45
FT                   /note="Targeting to peroxisomes"
FT                   /evidence="ECO:0000250|UniProtKB:P56589"
FT   REGION          120..136
FT                   /note="Interaction with PEX19"
FT                   /evidence="ECO:0000250|UniProtKB:P56589"
SQ   SEQUENCE   373 AA;  42137 MW;  A40FB0D560937300 CRC64;
     MFRSTWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES
     NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKTRPSNK LEIWEDLKII SFTRSIVAVY
     STCMLVVLLR VQLNIIGGYI YLDNAAVGKN GTTVLAPPDV QQQYLSSIQH LLGDGLTELI
     TVIKQAVQKI LGSVSLKHSL SLLDLEQKLK EIRDLVEQHK SSSWINNDGS KSLLCHYMMP
     DEETPLAVQA CGLSPRDVTT IKLLNETRDM LESPDFSTVL NTCLSRGFSR LLDNMAEFFR
     PTEQDLQHGN SINSLSSVSL PLAKIIPIIN GQIHSVCSET PSHFVQDLLM MEQVKDFAAN
     VYEAFSTPQQ LEK