ID   PEX3_CRILO              Reviewed;         373 AA.
AC   Q9JJK3;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Peroxisomal biogenesis factor 3;
DE   AltName: Full=Peroxin-3;
DE   AltName: Full=Peroxisomal assembly protein PEX3;
GN   Name=PEX3;
OS   Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Cricetulus.
OX   NCBI_TaxID=10030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=10848631; DOI=10.1091/mbc.11.6.2085;
RA   Ghaedi K., Tamura S., Okumoto K., Matsuzono Y., Fujiki Y.;
RT   "The peroxin pex3p initiates membrane assembly in peroxisome biogenesis.";
RL   Mol. Biol. Cell 11:2085-2102(2000).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis and integrity. Assembles
CC       membrane vesicles before the matrix proteins are translocated. As a
CC       docking factor for PEX19, is necessary for the import of peroxisomal
CC       membrane proteins in the peroxisomes. {ECO:0000269|PubMed:10848631}.
CC   -!- SUBUNIT: Interacts with PEX19. {ECO:0000250|UniProtKB:P56589}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000269|PubMed:10848631}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR   EMBL; AB035308; BAA97994.1; -; mRNA.
DR   AlphaFoldDB; Q9JJK3; -.
DR   SMR; Q9JJK3; -.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; ISS:UniProtKB.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0007031; P:peroxisome organization; ISS:UniProtKB.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; ISS:UniProtKB.
DR   InterPro; IPR006966; Peroxin-3.
DR   PANTHER; PTHR28080; PTHR28080; 1.
DR   Pfam; PF04882; Peroxin-3; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..373
FT                   /note="Peroxisomal biogenesis factor 3"
FT                   /id="PRO_0000208736"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..116
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..373
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..45
FT                   /note="Targeting to peroxisomes"
FT                   /evidence="ECO:0000250|UniProtKB:P56589"
FT   REGION          120..136
FT                   /note="Interaction with PEX19"
FT                   /evidence="ECO:0000250|UniProtKB:P56589"
SQ   SEQUENCE   373 AA;  42293 MW;  A0391AFD5DEE0991 CRC64;
     MLRSMWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES
     NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKNRPSNK LEIWEDLKII SFTRSIVAVY
     STCMLVVLLR VQLNIIGGYI YLDNATVGKN GTTVLAPPDV QQQYLSSIQH LLGDGLTELV
     TVIKQAVQRI LGSVSLKHSL SLLDLEQKLK EIRILVEQHR SPSWIDKDVS KSSLCQYMMP
     DEETPLAAQA YGLSPRDITT IKLLNETRDM LESPDFSTVL NTCLNRGFSR LLDNMAEFFR
     PTEQDLQHGN SINSLSSVSL PLAKIIPIVN GQIHSVCSDT PSHFVQDLLM MEQVKDFAAN
     VYEAFSTPQQ LEK