ID   PEX3_DICDI              Reviewed;         405 AA.
AC   Q54U86;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Peroxisome biogenesis factor 3;
DE   AltName: Full=Peroxin-3;
GN   Name=pex3; ORFNames=DDB_G0281213;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR   EMBL; AAFI02000040; EAL66903.1; -; Genomic_DNA.
DR   RefSeq; XP_640890.1; XM_635798.1.
DR   AlphaFoldDB; Q54U86; -.
DR   SMR; Q54U86; -.
DR   STRING; 44689.DDB0238047; -.
DR   PaxDb; Q54U86; -.
DR   EnsemblProtists; EAL66903; EAL66903; DDB_G0281213.
DR   GeneID; 8622947; -.
DR   KEGG; ddi:DDB_G0281213; -.
DR   dictyBase; DDB_G0281213; pex3.
DR   eggNOG; KOG4444; Eukaryota.
DR   HOGENOM; CLU_680480_0_0_1; -.
DR   InParanoid; Q54U86; -.
DR   OMA; YHNITQS; -.
DR   PhylomeDB; Q54U86; -.
DR   Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR   Reactome; R-DDI-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:Q54U86; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0005777; C:peroxisome; ISS:dictyBase.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0007031; P:peroxisome organization; ISS:dictyBase.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; IBA:GO_Central.
DR   InterPro; IPR006966; Peroxin-3.
DR   PANTHER; PTHR28080; PTHR28080; 1.
DR   Pfam; PF04882; Peroxin-3; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Peroxisome; Peroxisome biogenesis;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..405
FT                   /note="Peroxisome biogenesis factor 3"
FT                   /id="PRO_0000371404"
FT   TOPO_DOM        1..26
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..124
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        145..405
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   405 AA;  47669 MW;  F697D3A2F3A403C7 CRC64;
     MENFQFEDLS PNKVSKVYQD LKKFGSFLYN HKMGVFLVSF SSGVAYLYHN ITQSHKRKQI
     KLAKERVMTY FESTQKLSER EVDAIITKFI DENKILDKIQ TPSLASIRSE KDPSEKLKLT
     DQLKVSIITK LFSVLYIIPM VTIFNRLQIN LIGKYCYLDY VLYKDQEQHS MRLINQQTES
     NFINSRNNCY FFKDINFSQF INLIQEQIKI SLKDWKIDQQ SSFEGFLKLL INIRNNFEKK
     EIIASISSDN SLLKYLIPTE EEIDNLVQSQ KTPENDNDIE YQNLKMLYNE IRNIFESQKF
     YDVLKDSINQ SFLEFTKNLR EDFESTELKK QIDSIVLPDL PIEMEIPKPL VTMHNIILLP
     KINKQIGNII VNKKSIIEKI GSTDLINQLN YSVLTNDLDF NKVQF