ID   PEX3_KLULA              Reviewed;         483 AA.
AC   O94227; Q6CMX5;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Peroxisomal biogenesis factor 3;
DE   AltName: Full=Peroxin-3;
DE   AltName: Full=Peroxisomal membrane protein PAS3;
GN   Name=PEX3; Synonyms=PAS3; OrderedLocusNames=KLLA0E17017g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC MYA-539 / JBD100;
RA   Winkler A., Goedegebure R., Zonneveld B.J.M., Steensma H.Y.,
RA   Hooykaas P.J.J.;
RT   "Kluyveromyces lactis SKP1 can complement a mutation in CTF13, a gene
RT   coding for a centromeric protein of Saccharomyces cerevisiae.";
RL   Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Single-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR   EMBL; AF012338; AAD01495.1; -; Genomic_DNA.
DR   EMBL; CR382125; CAG99801.1; -; Genomic_DNA.
DR   RefSeq; XP_454714.1; XM_454714.1.
DR   AlphaFoldDB; O94227; -.
DR   SMR; O94227; -.
DR   STRING; 28985.XP_454714.1; -.
DR   EnsemblFungi; CAG99801; CAG99801; KLLA0_E16963g.
DR   GeneID; 2894499; -.
DR   KEGG; kla:KLLA0_E16963g; -.
DR   eggNOG; KOG4444; Eukaryota.
DR   HOGENOM; CLU_017002_0_0_1; -.
DR   InParanoid; O94227; -.
DR   OMA; KQRFIQT; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR   GO; GO:0032581; P:ER-dependent peroxisome organization; IEA:EnsemblFungi.
DR   GO; GO:0045033; P:peroxisome inheritance; IEA:EnsemblFungi.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; IEA:EnsemblFungi.
DR   InterPro; IPR006966; Peroxin-3.
DR   PANTHER; PTHR28080; PTHR28080; 1.
DR   Pfam; PF04882; Peroxin-3; 1.
PE   3: Inferred from homology;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..483
FT                   /note="Peroxisomal biogenesis factor 3"
FT                   /id="PRO_0000208743"
FT   TOPO_DOM        1..14
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..483
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          119..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          230..253
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  55118 MW;  91F3B5D4B00D3955 CRC64;
     MTGNRSLVQR HRKKFVVSSV LFATLFATCA ITVYFSKRWL YKQHLKMTEQ RFVKEQIKRR
     FVQTQQDSLY TLYELMPVMT LVLAKDFDLD SIVEALKGKK LQKKLSKGEI AGNELENEGL
     SSGMSAMTPA PSVSAKSPQS ADTTSVSETS TKSKAELWDD LKLKAITKII ILSYTTSLLM
     LLTRLQLNIL ARREYLDTAI NSAMEKEREK KANQYSVLSW FSSWITEKSN NLPSEKADPR
     NSDGTIDTDT RSIASTANPE KSRYVNEQAF LSLSWWLLNR GYLQYKSIIE QLVKEEFQNS
     NPRDIMTMDE FSGKISKIFV TTNKQFFQQP QSNEMFISCL LPEPNLERFV LQQTLEQDAL
     KVLYEDNLLL KQLVQETNKC LQSPGTWIVL ESLIDETFHT IMEQIEDNVN SKSKPKSNDD
     DTKVVDISKN SYQIALFSIA TKDCTNEMLK AGLVSMNNKF LQKLHSISAL DDLSACVYSN
     FGL