ID   PEX3_MACFA              Reviewed;         373 AA.
AC   Q60HE1;
DT   29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Peroxisomal biogenesis factor 3;
DE   AltName: Full=Peroxin-3;
DE   AltName: Full=Peroxisomal assembly protein PEX3;
GN   Name=PEX3; ORFNames=QnpA-14710;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Parietal cortex;
RA   Kusuda J., Osada N., Tanuma R., Hirata M., Sugano S., Hashimoto K.;
RT   "Isolation and characterization of cDNA for macaque neurological disease
RT   genes.";
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in peroxisome biosynthesis and integrity. Assembles
CC       membrane vesicles before the matrix proteins are translocated. As a
CC       docking factor for PEX19, is necessary for the import of peroxisomal
CC       membrane proteins in the peroxisomes (By similarity).
CC       {ECO:0000250|UniProtKB:P56589}.
CC   -!- SUBUNIT: Interacts with PEX19. {ECO:0000250|UniProtKB:P56589}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:P56589}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:P56589}.
CC   -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR   EMBL; AB125186; BAD51974.1; -; mRNA.
DR   RefSeq; XP_005552063.1; XM_005552006.2.
DR   AlphaFoldDB; Q60HE1; -.
DR   SMR; Q60HE1; -.
DR   STRING; 9541.XP_005552063.1; -.
DR   Ensembl; ENSMFAT00000015534; ENSMFAP00000041258; ENSMFAG00000041371.
DR   GeneID; 101865844; -.
DR   KEGG; mcf:101865844; -.
DR   CTD; 8504; -.
DR   VEuPathDB; HostDB:ENSMFAG00000041371; -.
DR   eggNOG; KOG4444; Eukaryota.
DR   GeneTree; ENSGT00390000008481; -.
DR   OMA; WSLQMAI; -.
DR   OrthoDB; 891261at2759; -.
DR   Proteomes; UP000233100; Chromosome 4.
DR   Bgee; ENSMFAG00000041371; Expressed in adult mammalian kidney and 13 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005777; C:peroxisome; ISS:UniProtKB.
DR   GO; GO:0032994; C:protein-lipid complex; IEA:Ensembl.
DR   GO; GO:0008289; F:lipid binding; IEA:Ensembl.
DR   GO; GO:0007031; P:peroxisome organization; ISS:UniProtKB.
DR   GO; GO:0045046; P:protein import into peroxisome membrane; ISS:UniProtKB.
DR   InterPro; IPR006966; Peroxin-3.
DR   PANTHER; PTHR28080; PTHR28080; 1.
DR   Pfam; PF04882; Peroxin-3; 3.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..373
FT                   /note="Peroxisomal biogenesis factor 3"
FT                   /id="PRO_0000208738"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        37..116
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        141..373
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          1..45
FT                   /note="Targeting to peroxisomes"
FT                   /evidence="ECO:0000250|UniProtKB:P56589"
FT   REGION          120..136
FT                   /note="Interaction with PEX19"
FT                   /evidence="ECO:0000250|UniProtKB:P56589"
SQ   SEQUENCE   373 AA;  42156 MW;  878C095D74CCD357 CRC64;
     MLRSVWNFLK RHKKKCIFLG TVLGGVYILG KYGQKKIREI QEREAAEYIA QARRQYHFES
     NQRTCNMTVL SMLPTLREAL MQQLNSESLT ALLKNRPSNK LEIWEDLKII SFTRSIVAVY
     STCMLVVLLR VQLNIIGGYI YLDNAAVGKN GTTILAPPDV QQQYLSSIQH LLGDGLTELI
     TVIKQAVQKI LGSVSLKHSL SLLDLEQKLK EIRNLVEQHK SSSWINKDGS KSLLCHYMMP
     DEETPLAVQA CGLSPRDITT IKLLNETRDM LESPDFSTVL NTCLNRGFSR LLDNMAEFFR
     PTEQDLQHGN SMNSLSSVSL PLAKIIPIVN GQIHSVCSET PSHFVQDLLT MEQVKDFAAN
     VYEAFSTPQQ LEK