ID   PEX3_PICPA              Reviewed;         455 AA.
AC   Q92262;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Peroxisomal biogenesis factor 3;
DE   AltName: Full=Peroxin-3;
DE   AltName: Full=Peroxisomal membrane protein PAS2;
GN   Name=PEX3; Synonyms=PAS2;
OS   Komagataella pastoris (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=4922;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8955066; DOI=10.1074/jbc.271.51.32483;
RA   Subramani S.;
RT   "Protein translocation into peroxisomes.";
RL   J. Biol. Chem. 271:32483-32486(1996).
CC   -!- FUNCTION: Involved in peroxisome biosynthesis.
CC   -!- INTERACTION:
CC       Q92262; I6LAD1: ATG30; NbExp=3; IntAct=EBI-8849514, EBI-8849497;
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Single-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the peroxin-3 family. {ECO:0000305}.
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DR   EMBL; Z72390; CAA96530.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q92262; -.
DR   SMR; Q92262; -.
DR   IntAct; Q92262; 1.
DR   MINT; Q92262; -.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR   GO; GO:0007031; P:peroxisome organization; IEA:UniProtKB-KW.
DR   InterPro; IPR006966; Peroxin-3.
DR   PANTHER; PTHR28080; PTHR28080; 1.
DR   Pfam; PF04882; Peroxin-3; 1.
PE   1: Evidence at protein level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..455
FT                   /note="Peroxisomal biogenesis factor 3"
FT                   /id="PRO_0000208745"
FT   TOPO_DOM        1..15
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        16..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        34..455
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          113..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        113..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   455 AA;  51973 MW;  6853C5EA5C67EC34 CRC64;
     MLEYTAGLIR RNKKKFLISS GIIGVGYYVT KTINNKIQEF QNRIREENFA KEQIKRRFHQ
     TQSDCYMTFL SLLPVLCEPI MDDLPVETIT KQLQIRRLEK QIGNKDVKNS GSTVLSDDFS
     TSQEGAISED TNKPPELKSK NQLWQELKIK AITRFLTLIY CESLLIVFLH LQLNILSRKS
     YLETAIRLAS ETQGIDLVDQ ESNGDFSGNT QDENLSEQAF LSFSWWLLNK GWLEIKNKIE
     PCVEQHFGGI NPRQQLKINE FAELLNKCQN CIDLKVLNLT EEDIHLGVGV IEDQSQPVGR
     KSTNFITNAL LPPKEFEFFL LQQTNDLDFL SRFNNNIVNT ESLNMLLDEL NNYLNNADIN
     LIVNKLATLG ITKVLDEIVL NLLQKNRPNP ISDMNIRDID LNDFPPYKLA ALLANITKQS
     ISLTNNSVEN PILADLNNLP ELNDLSASVY SNFDP