PEX5_CANAL
ID PEX5_CANAL Reviewed; 592 AA.
AC O74711; A0A1D8PL28; Q59UT0;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Peroxisomal targeting signal receptor;
DE Short=PTS1 receptor;
DE Short=PTS1R;
DE AltName: Full=Peroxin-5;
GN Name=PEX5; OrderedLocusNames=CAALFM_C400150CA;
GN ORFNames=CaO19.13085, CaO19.5640;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 297-592.
RC STRAIN=ATCC 64385 / 1001;
RX PubMed=9778800;
RX DOI=10.1002/(sici)1097-0061(19980915)14:12<1147::aid-yea297>3.0.co;2-7;
RA Navarro-Garcia F., Perez-Diaz R., Negredo A., Pla J., Nombela C.;
RT "Cloning and sequence of a 3.835 kbp DNA fragment containing the HIS4 gene
RT and a fragment of a PEX5-like gene from Candida albicans.";
RL Yeast 14:1147-1157(1998).
CC -!- FUNCTION: Binds to the C-terminal PTS1-type tripeptide peroxisomal
CC targeting signal (SKL-type) and plays an essential role in peroxisomal
CC protein import. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Its
CC distribution appears to be dynamic. It is probably a cycling receptor
CC found mainly in the cytoplasm and as well associated to the peroxisomal
CC membrane (By similarity). {ECO:0000250}.
CC -!- PTM: Ubiquitination at Cys-10 is UBC4-independent but requires the
CC presence of PEX4. Ubiquitination at Lys-22 is UBC4-dependent (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000305}.
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DR EMBL; CP017626; AOW28808.1; -; Genomic_DNA.
DR EMBL; AJ003115; CAA05870.1; -; Genomic_DNA.
DR RefSeq; XP_713321.1; XM_708228.2.
DR AlphaFoldDB; O74711; -.
DR SMR; O74711; -.
DR STRING; 237561.O74711; -.
DR PRIDE; O74711; -.
DR GeneID; 3645026; -.
DR KEGG; cal:CAALFM_C400150CA; -.
DR CGD; CAL0000177775; PEX5.
DR VEuPathDB; FungiDB:C4_00150C_A; -.
DR eggNOG; KOG1125; Eukaryota.
DR HOGENOM; CLU_013516_3_0_1; -.
DR InParanoid; O74711; -.
DR OrthoDB; 588648at2759; -.
DR PRO; PR:O74711; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0005829; C:cytosol; ISO:CGD.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:CGD.
DR GO; GO:0005052; F:peroxisome matrix targeting signal-1 binding; ISO:CGD.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; ISO:CGD.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IMP:CGD.
DR GO; GO:0006631; P:fatty acid metabolic process; ISO:CGD.
DR GO; GO:0016558; P:protein import into peroxisome matrix; IMP:CGD.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; ISO:CGD.
DR GO; GO:0006625; P:protein targeting to peroxisome; IMP:CGD.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130; PTHR10130; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 4.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Isopeptide bond; Membrane; Peroxisome; Protein transport;
KW Reference proteome; Repeat; Thioester bond; TPR repeat; Transport;
KW Ubl conjugation.
FT CHAIN 1..592
FT /note="Peroxisomal targeting signal receptor"
FT /id="PRO_0000106308"
FT REPEAT 295..329
FT /note="TPR 1"
FT REPEAT 330..363
FT /note="TPR 2"
FT REPEAT 440..473
FT /note="TPR 3"
FT REPEAT 475..507
FT /note="TPR 4"
FT REPEAT 509..541
FT /note="TPR 5"
FT REGION 22..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 10
FT /note="Glycyl cysteine thioester (Cys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
FT CROSSLNK 22
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 592 AA; 67324 MW; FA5B271F220B38E6 CRC64;
MSFVGGGSEC SVNGNAVAQF NKHTQQDRSL QQQVANQHGN VAQNQGFKKD NLMNVRDRAN
LDQFMNNGAP QNSFQFQPMR HELNTIQNQP NAIHQQQSNW SQDFVAQSPS AQITTPIAKT
GSPVNAQWAS EFSQAPATQQ HNQRPGQFGP RLGGYRPMMG MSMAYQSQPQ QQQQQQHNQE
PQVDWENQFK EIEELTNKAE EVEEIQREQS PEIVVDDKYQ ATFQEVWDSL NSESFENDFI
NQQYEDFKRT QKDGFPADMN QWEKDFAKYA STRAHFGDYQ FEDKQSNQFL DLPKDQDPYE
IGLQLMENGA KLSEAALAFE AAIQRDENHV DAWLKLGEVQ TQNEKEIAGI SALEKCLELH
PENSEALMNL AISYINEGYD NAAFATLERW ISTKYPQIVE KARQENPTIT DEDRFSLNKR
VTELFLNAAQ LSPNQASMDA DVQMGLGVLF YANEEFDKTI DCFKAALSIR PDDAILWNRL
GASLANSNRS EEAVDAYFKA LQLKPTFVRA RYNLGVSCIN IGCYKEAAEH LLSGLSMHQV
EGVDTVSTLN HNQSTSLTET LKRAFIAMER RDLLELVKPN MDLNQFRGEF SF
