PEX5_CANGA
ID PEX5_CANGA Reviewed; 590 AA.
AC Q6FM42;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=Peroxisomal targeting signal receptor;
DE Short=PTS1 receptor;
DE Short=PTS1R;
DE AltName: Full=Peroxin-5;
GN Name=PEX5; OrderedLocusNames=CAGL0K11209g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Binds to the C-terminal PTS1-type tripeptide peroxisomal
CC targeting signal (SKL-type) and plays an essential role in peroxisomal
CC protein import. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Peroxisome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Its
CC distribution appears to be dynamic. It is probably a cycling receptor
CC found mainly in the cytoplasm and as well associated to the peroxisomal
CC membrane (By similarity). {ECO:0000250}.
CC -!- PTM: Ubiquitination at Cys-6 is UBC4-independent but requires the
CC presence of PEX4. Ubiquitination at Lys-18 is UBC4-dependent (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal targeting signal receptor
CC family. {ECO:0000305}.
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DR EMBL; CR380957; CAG61665.1; -; Genomic_DNA.
DR RefSeq; XP_448702.1; XM_448702.1.
DR AlphaFoldDB; Q6FM42; -.
DR SMR; Q6FM42; -.
DR STRING; 5478.XP_448702.1; -.
DR PRIDE; Q6FM42; -.
DR EnsemblFungi; CAG61665; CAG61665; CAGL0K11209g.
DR GeneID; 2890061; -.
DR KEGG; cgr:CAGL0K11209g; -.
DR CGD; CAL0134877; PEX5.
DR VEuPathDB; FungiDB:CAGL0K11209g; -.
DR eggNOG; KOG1125; Eukaryota.
DR HOGENOM; CLU_013516_3_0_1; -.
DR InParanoid; Q6FM42; -.
DR OMA; SQFTKHV; -.
DR Proteomes; UP000002428; Chromosome K.
DR GO; GO:0005829; C:cytosol; ISO:CGD.
DR GO; GO:1990429; C:peroxisomal importomer complex; IEA:EnsemblFungi.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:CGD.
DR GO; GO:0005777; C:peroxisome; ISO:CGD.
DR GO; GO:0005052; F:peroxisome matrix targeting signal-1 binding; ISO:CGD.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:EnsemblFungi.
DR GO; GO:0016560; P:protein import into peroxisome matrix, docking; ISO:CGD.
DR Gene3D; 1.25.40.10; -; 1.
DR InterPro; IPR024111; PEX5/PEX5L.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR001440; TPR_1.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR10130; PTHR10130; 1.
DR Pfam; PF00515; TPR_1; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50005; TPR; 5.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Isopeptide bond; Membrane; Peroxisome; Protein transport;
KW Reference proteome; Repeat; Thioester bond; TPR repeat; Transport;
KW Ubl conjugation.
FT CHAIN 1..590
FT /note="Peroxisomal targeting signal receptor"
FT /id="PRO_0000106309"
FT REPEAT 285..319
FT /note="TPR 1"
FT REPEAT 320..353
FT /note="TPR 2"
FT REPEAT 424..457
FT /note="TPR 3"
FT REPEAT 459..491
FT /note="TPR 4"
FT REPEAT 493..525
FT /note="TPR 5"
FT REGION 18..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CROSSLNK 6
FT /note="Glycyl cysteine thioester (Cys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
FT CROSSLNK 18
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in ubiquitin)"
FT /evidence="ECO:0000250"
SQ SEQUENCE 590 AA; 66531 MW; 48359118B5F111BE CRC64;
MNMTDCSVGS NPLAQLNKHA QGQGSSLSNT HVRHSGGVSG SNVFRSGQNV VSEDGRQQLN
SFMSQPMRLG EDKMHPATPM GSSMGNAIGG SMMQVDDSSM RSAGDSQWTR EFRQNTAGKT
NMAQEMGSSG AAMANSNAWK FRYSPMTNVN NTAPLRPFNN IIRQKERANG LETGDIAWND
KFDELEKEVS DKLNFKDGET VEKMDTGAEM QQDNLETGDS TDYQKEFQEV WDSIQQDTEE
MLSYKDDYED MLNDTDFERS FLGKRAVESL EYKFENPSEN QYMNNPNAYQ IGCILMENGA
KLSEAALAFE AAIKQDPKHV DAWLKLGIVQ IQNEKELNGM SALETCLKLD PNNLEAMKNL
AISYINEGYD MSAYNMLNRW ADTKYPGFYN SAELEGKRDE HENIHSKMTR RFLSLVNRIN
SVDPDIQLCL GLLFYANDEF DRTIDCFQAA LKVNPNDELM WNRLGASLAN SNRSEEAIQA
YHRALQLKPS FVRARYNLAV SSMNIGCYKE AAEHLLTALS MHDVEGEFEV QSTRSNSISS
ADKYSFSGFK PTDNLLETLK RVFISMGRDD LLDRVRPGMD LSQFRNEFTF
